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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
0.9
Temp.:
25 °C
Remarks on result:
other: No information on pH value is given
Details on results:
No information on pH value is given.

The equation for the regression line for the above test conditions is given below.

log Pow = 1.419 · log k + 1.003

Log Pow

Measured values

Mean value

0.9

0.9

0.9

Preliminary estimates obtained using the partition coefficient calculation software, ClogP*3and Kowwin*4, are log Pow = 0.62 and 0.45, respectively.

*3 ClogP v4.0 (BioByte Corp.)

*4 Kowwin vl.66 (U.S Environmental Protection Agency)

Description of key information

log Pow: 0.9 at 25 °C
(OECD 117 Guideline, HPLC method)

Key value for chemical safety assessment

Log Kow (Log Pow):
0.9
at the temperature of:
25 °C

Additional information

No information on pH value is given.