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EC number: 221-499-3 | CAS number: 3121-61-7
- Life Cycle description
- Uses advised against
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- Appearance / physical state / colour
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- Density
- Particle size distribution (Granulometry)
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
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- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96h) = 4.6 mg/L (measured, arithm. mean) (Salmo gairdneri, EPA OTS 797.1400), RA
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 4.6 mg/L
Additional information
Since no data on the short-term toxicity of 2-methoxyethyl acrylate (CAS 3121-61-7) to fish are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 read-across to another structurally related analogue substance was conducted. Read-across data from ethyl acrylate (CAS 140 -88 -5) were used, which was considered suitable for read-across.
The key study was conducted with ethyl acrylate according to GLP and US EPA guideline OTS 797.1400 using rainbow trout (Salmo gairdneri, new name: Oncorhynchus mykiss) as test organism. Within this flow-through study, nominal test concentrations of 0, 0.44, 0.88, 1.8, 3.5, 7.0 and 14 mg/L were applied with corresponding mean measured concentrations of 0, 0.34, 0.78, 1.7, 3.3, 6.5 and 13 mg/L (recoveries between 77 and 95%, mean: 90 ± 6.6 %). As a result, a 96h-LC50 value of 4.6 mg/L was determined based on measured concentrations (arithmetic mean) (ABC Laboratories, 1990). Behavioral/sublethal effects noted during the study included on-bottom orientation, surfacing, dark discolorating, quiescence and loss of equilibrium (NOEC 0.78 mg/L).
Due to structural and property similarities with the tested analogue substance, it can be concluded that the above result also applies to 2-methoxyethyl acrylate (CAS 3121-61-7). For details see analogue justification in the overall summary of Chap 6.1 and in Chapter 13 of the Technical Dossier.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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