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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
European Union Risk Assessment Report - o-Anisidin
Author:
European Chemicals Bureau
Year:
2002
Bibliographic source:
European Commission, Joint Research Center, EUR 19834 EN, 2nd Priority list, Volume 15

Materials and methods

Principles of method if other than guideline:
Acute toxicity tests: duration 4-14 days; static (14d), flow-through (14d) and semi-static (4d);

Test material

Constituent 1
Chemical structure
Reference substance name:
o-anisidine
EC Number:
201-963-1
EC Name:
o-anisidine
Cas Number:
90-04-0
Molecular formula:
C7H9NO
IUPAC Name:
2-methoxyaniline
Details on test material:
Commercially available o-anisidine with a purity of >=99%;

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
other: Poecilia reticulata, Oryzias latipes

Study design

Test type:
other: static (14d), flow-through (14d) and semi-static (4d)
Water media type:
freshwater
Limit test:
no
Remarks on exposure duration:
4-14

Results and discussion

Effect concentrationsopen allclose all
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
18 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: static, Poecilia reticulata
Duration:
14 d
Dose descriptor:
EC50
Effect conc.:
18 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
behaviour
Remarks on result:
other: static, Poecilia reticulata
Duration:
14 d
Dose descriptor:
NOEC
Effect conc.:
25 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
not specified
Remarks on result:
other: Oryzias latipes, flow-through
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Oryzias latipes, flow-through
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
196 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Oryzias latipes, flow-through

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
In different toxicity tests on the fish species Poecilia reticulata and Oryzias latipes the following effect concentrations were determined for the submission substance:
- Poecilia reticulata, 14d, static: EC50 = 18 mg/L; LC50 = 165 mg/L;
- Oryzias latipes: a) 14 d, flow through: NOEC = 25 mg/L, LC50 >100 mg/L; b) 4d, semi-static: LC50 = 196 mgL;
Executive summary:

In different toxicity tests on the fish species Poecilia reticulata and Oryzias latipes the following effect concentrations were determined for the submission substance:

Poecilia reticulata, 14d, static: EC50 = 18 mg/L; LC50 = 165 mg/L; -

Oryzias latipes: a) 14 d, flow through: NOEC = 25 mg/L, LC50 >100 mg/L; b) 4d, semi-static: LC50 = 196 mgL;