Registration Dossier
Registration Dossier
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EC number: 270-478-5 | CAS number: 68442-22-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a delayed contact hypersensitivity study in Guinea pigs (Buehler technique), 20 Hartley strain Guinea pigs were induced with 5% w/v test substance and then challenged with 1% w/v (Morris T.D., 1997). Irritation was noted in 3/20 animals following the 24 hour challenge phase. This irritation did not persist to 48 hours indicating an irritation response rather than a skin sensitization response. The test substance does not appear to be a sensitizer in the guinea pig.
Migrated from Short description of key information:
The substance is not skin-sensitizing to guinea gigs
Respiratory sensitisation
Endpoint conclusion
- Additional information:
no data available
Migrated from Short description of key information:
no data available
Justification for classification or non-classification
In accordance with EU CLP (Regulation (EC) No. 1272/2008), this substance does not meet the criteria for classification as a skin sensitizer.
No data are available for respiratory sensitization.
The substance is therefore not classifiable for this endpoint in accordance to the CLP Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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