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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: MIGRATED DATASET. Original reference not translated.

Data source

Reference
Title:
No information
Author:
Gizhlaryan, M.S. et al.: Gig. Sanit. 7, 77-78 (1986)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data
GLP compliance:
no
Remarks:
GLP was not mandatory at the tiem of the study

Test material

Constituent 1
Chemical structure
Reference substance name:
3,4-dichlorobut-1-ene
EC Number:
212-079-0
EC Name:
3,4-dichlorobut-1-ene
Cas Number:
760-23-6
Molecular formula:
C4H6Cl2
IUPAC Name:
3,4-dichlorobut-1-ene
Details on test material:
- Name of test material (as cited in study report): 3,4-dichlorobut-1-ene
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
over the whole gestation period
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.01, 0.1 or 1.0 mg/kg bw
Basis:

Control animals:
yes
Details on study design:
Sex: female

Results and discussion

Results: maternal animals

Maternal developmental toxicity

Details on maternal toxic effects:
Maternal toxic effects:yes

Details on maternal toxic effects:
The dose of 1.0 mg/kg bw led to a significant enhancement of post-implantation losses. 0.1 mg/kg bw caused an increase of pre-implantation losses. Histological examinations revealed changes of placenta.

Results (fetuses)

Details on embryotoxic / teratogenic effects:
Embryotoxic / teratogenic effects:yes

Details on embryotoxic / teratogenic effects:
Histological examinations revealed haemorrhages in embryos (brain and peritoneum) as well as oedema and changes in liver, brain and kidneys. The dose of 0.01 mg/kg bw was tolerated without any damages.

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion