Registration Dossier
Registration Dossier
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EC number: 248-421-0 | CAS number: 27344-41-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In an in vivo study according to the method described by Magnusson and Kligman, 30 female guinea pigs were used (20 animals as test group, and 10 animals as control group). During the induction procedure the test group was exposed to 5% test substance via intradermal injection and 25% test substance via topical application. The control group was exposed to vehicle only during this procedure. All animals were challenged with 25% test substance and vehicle (RCC 1990).
At challenge, 0/20 (0%) positive responses were noted in the test group and control group after 24 h and 48 h, respectively.This result is supported by a study with the test substance which was tested using a Maurer optimisation test (CIBA, 1975).
Migrated from Short description of key information:
Skin: not sensitising, (RCC 1990) OECD TG 406
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
no data available
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified for skin sensitisation under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for skin sensitisation under Regulation (EC) No. 1272/2008Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
