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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Although this pre-dates international guidelines for acute oral toxicity studies and GLP, in accordance with REACH Annex XI, Section 1.1.2, the study was conducted under sound scientific principles of acute toxicity studies. The study is therefore considered adequate for contributing evidence towards this endpoint in a weight of evidence approach.

Data source

Reference
Reference Type:
publication
Title:
Evaluation of acute toxicity of phenylglycidyl ether with special regard to percutaneous absorption
Author:
T. Czajkowska
Year:
1972
Bibliographic source:
Czajkowska, T., Stetkiewicz, J. (1972) Evaluation of acute toxicity of phenylglycidyl ether with special regard to percutaneous absorption. Medycyna Pracy, 23: 363-371.

Materials and methods

Principles of method if other than guideline:
Rats were given single doses of phenylglycidyl ether by oral gavage and the observation period was 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-epoxypropyl phenyl ether
EC Number:
204-557-2
EC Name:
2,3-epoxypropyl phenyl ether
Cas Number:
122-60-1
Molecular formula:
C9H10O2
IUPAC Name:
2-(phenoxymethyl)oxirane

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 600 mg/kg bw
Based on:
test mat.
Gross pathology:
Histopathological examination of the livers in the animals that died revealed nodule formation and necrosis of the liver parenchyma.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 of phenylglycidyl ether to Wistar rats was estimated as 2600 mg/kg.

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