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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
Not reported
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: There were not enough available information to adequately rate the quality of this study.

Data source

Reference
Reference Type:
publication
Title:
Evaluation of acute toxicity of phenylglycidyl ether with special regard to percutaneous absorption
Author:
Czajkowska, T.
Year:
1972
Bibliographic source:
Czajkowska, T. and Stetkiewicz, J. (1972) Evaluation of acute toxicity of phenylglycidyl ether with special regard to percutaneous absorption. Med. Pr., 23; 363-371.

Materials and methods

Principles of method if other than guideline:
A single application of PGE was made to the skin of white Wistar Rats, the observation period was 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-epoxypropyl phenyl ether
EC Number:
204-557-2
EC Name:
2,3-epoxypropyl phenyl ether
Cas Number:
122-60-1
Molecular formula:
C9H10O2
IUPAC Name:
2-(phenoxymethyl)oxirane

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
2 160 mg/kg bw
Based on:
test mat.
Clinical signs:
other: Histopathological examination of the skin 18 hours after treatment revealed necrosis, epithelial exfoliation and oedema. After 14 days, scar formation, acanthosis and swelling of the dermis were observed.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The results of this study estimate the dermal LD50 of phenylglycidyl ether to be 2160 mg/kg bw.