N,N'-bis(1,4-dimethylpentyl)-p-phenylenediamine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: limited but acceptable documented study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Principles of method if other than guideline:

other: acute dermal toxicity study

GLP compliance:

no

Test type:

other: acute dermal toxicity study

Test material

Test material information

Constituent 1

Reference substance name:

N,N'-bis(1,4-dimethylpentyl)-p-phenylenediamine

EC Number:

221-375-9

EC Name:

N,N'-bis(1,4-dimethylpentyl)-p-phenylenediamine

Cas Number:

3081-14-9

Molecular formula:

C20H36N2

IUPAC Name:

N1,N4-bis(5-methylhexan-2-yl)benzene-1,4-diamine

Details on test material:

Santoflex 77 (purity 96 %)

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

Doses:

1260, 2000, 3160, 5010, 7940 mg/kg bw

No. of animals per sex per dose:

1 per dose

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 3 160 mg/kg bw

Based on:

test mat.

Remarks on result:

other: death occured at 5010 mg/kg bw and higher, clinical signs like reduced appetite and activity (survivors), increased weakness, collapse and death (2 to 3 days) occured after application

Any other information on results incl. tables

Mortality

1260 mg/kg: male -, female (0/1), combinded (0/1)

2000 mg/kg: male (0/1), female -, combinded (0/1)

3160 mg/kg: male -, female (0/1), combinded (0/1)

5010 mg/kg: male (1/1), female -, combinded (1/1)

7940 mg/kg: male -, female (1/1), combinded (1/1)

Time of mortality: 2 to 3 days after test substance application

Clinical signs:

Reduced appetite and activity (three to seven days in survivors), increasing weakness, collapse, and death

Gross autopsy findings:

Decedents: lung hyperemia, liver discoloration, enlarged gall bladder, and gastrointestinal inflammation

Survivors (14 days): animal # 1: viscera appeared normal, animals #2 and #3: slight discoloration of liver and kidneys