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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Although conducted prior to current protocol or GLP requirements, the study conformed to recognized protocols current at the time.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report Date:
1969

Materials and methods

Principles of method if other than guideline:
Performed prior to current protocol or GLP requirements but by a method acceptable at the time.
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Name of test material: 5-(sodiosulfo)isophthalic acid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
Intraperitoneal injection of a 10% solution in water.
Doses:
200 to 3200 mg/kg bwt
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
800 mg/kg bw
Mortality:
Mortality occurred from 1 hour to 7 days following exposure.
Clinical signs:
In affected animals, clinical signs included normal to very weak; prostration; labored respiration; tremors; and rough coat.
Body weight:
After a 2-week post-treatment observation period, weight gains of 5+g were noted.

Applicant's summary and conclusion

Conclusions:
The test material was slightly toxic to rats following intraperitoneal administration.