Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1974
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Very limited reported study
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Examination of acute oral toxicity in mice after ip administration
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']cuprate(2-)
EC Number:
237-864-5
EC Name:
Disodium [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']cuprate(2-)
Cas Number:
14025-15-1
Molecular formula:
C10H12CuN2O8.2Na
IUPAC Name:
Copper(2+) ion disodium 2-({2-[bis(carboxylatomethyl)amino]ethyl} (carboxylatomethyl)amino)acetate
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Name: Cutrilon (copper complex of Trilon B)
Appearance: solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
not indicated
No. of animals per sex per dose:
not indicated
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
ca. 200 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Clinical signs consisted of: dyspnoea, spasms, staggering gait, apathy, tearing, and animals were laying down.

At necropsy the animals did not show presence of substance accumulation.

Applicant's summary and conclusion

Conclusions:
The acute LD50 value via ip administration in mice is ca. 200 mg/kg bw.