Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 305-500-5 | CAS number: 94581-02-9 Coke formed by cooling, to approximately 1500°C, hot acetylene containing split gases from aromatic residual oil produced from ethylene production by naphtha cracking at 800°C to 900°C (427°F to 482°F) (coal derived).
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04/2003 to 10/2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- Buehler test
Test material
- Reference substance name:
- Carbon black
- EC Number:
- 215-609-9
- EC Name:
- Carbon black
- Cas Number:
- 1333-86-4
- IUPAC Name:
- methane
- Details on test material:
- CARBON BLACK XPB 295
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- female
- Details on test animals and environmental conditions:
- in accordance with the current OECD/EU testing guidelines
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- epidermal induction with 50% of the test material in sterile water; epidermal challenge with 50% of the test material in sterile water
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- epidermal induction with 50% of the test material in sterile water; epidermal challenge with 50% of the test material in sterile water
- No. of animals per dose:
- 20 animals in the test group, 10 animals in the control group
- Details on study design:
- in accordance with the current OECD/EU testing guidelines
- Challenge controls:
- in accordance with the current OECD/EU testing guidelines
- Positive control substance(s):
- yes
- Remarks:
- alpha-hexylcinnamaldehyde
Study design: in vivo (LLNA)
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- Statistics:
- not performed
Results and discussion
- Positive control results:
- 60% response
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 50% in sterile water
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- dark coloration at treated sites
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 50% in sterile water. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: dark coloration at treated sites.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 50% in sterile water
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- dark coloration at treated sites
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 50% in sterile water. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: dark coloration at treated sites.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Carbon Black XPB 295 was not sensitising in guinea pigs (Buehler test performed according to OECD guideline 406)
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