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EC number: 202-715-5 | CAS number: 98-94-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 6th June 1977 to 11thNovember 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not compliant with guidelines or GLP. Skin was abraded prior to application of the test substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was applied to rabbits to determine its potential skin irritancy.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclohexyldimethylamine
- EC Number:
- 202-715-5
- EC Name:
- Cyclohexyldimethylamine
- Cas Number:
- 98-94-2
- Molecular formula:
- C8H17N
- IUPAC Name:
- N,N-dimethylcyclohexanamine
- Details on test material:
- - Name of test material (as cited in study report): Polycat 8
- Molecular formula (if other than submission substance): Not documented
- Molecular weight (if other than submission substance): Not documented
- Smiles notation (if other than submission substance): Not documented
- InChl (if other than submission substance): Not documented
- Structural formula attached as image file (if other than submission substance): see Fig. Not documented
- Substance type: Not documented
- Physical state: Liquid
- Analytical purity: Not documented
- Impurities (identity and concentrations): Not documented
- Composition of test material, percentage of components: Not documented
- Isomers composition: Not documented
- Purity test date: Not documented
- Lot/batch No.: 73-270 CJ
- Expiration date of the lot/batch: Not documented
- Radiochemical purity (if radiolabelling): Not documented
- Specific activity (if radiolabelling): Not documented
- Locations of the label (if radiolabelling): Not documented
- Expiration date of radiochemical substance (if radiolabelling): Not documented
- Stability under test conditions: Not documented
- Storage condition of test material: Not documented
- Other: Not documented
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not documented
- Age at study initiation: Not documented
- Weight at study initiation: 2.33 - 2.55kg
- Housing: Not documented
- Diet (e.g. ad libitum): Not documented
- Water (e.g. ad libitum): Not documented
- Acclimation period: Not documented
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not documented
- Humidity (%): Not documented
- Air changes (per hr): Not documented
- Photoperiod (hrs dark / hrs light): Not documented
IN-LIFE DATES: From: 10 November 1977 To: 11 November 1977
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: Intact and abraded shaved skin
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5ml - Duration of treatment / exposure:
- No information provided
- Observation period:
- 30 days post application. Readings were made at 4, 24, 48 and 72 hours post application.
- Number of animals:
- 6 animals
- Details on study design:
- No information provided
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4 hours
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin
- Irritation parameter:
- other: Corrosion Score
- Basis:
- mean
- Time point:
- other: 4 hours
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin
- Irritation parameter:
- other: Corrosion Score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin
- Irritation parameter:
- other: Corrosion Score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin
- Irritation parameter:
- other: Corrosion Score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: For both intact and abraded skin
- Irritant / corrosive response data:
- Following exposure to rabbits, the test substance was considered to be extremely irritating to the skin of the rabbits.
- Other effects:
- No additional information
Any other information on results incl. tables
No additional information provided
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Under the conditions of this study, the test substance, DMCHA, should be considered to be irritating, based on the results observed following exposure to rabbits. Based on these results, the test substance should be classified as a Category 1B skin corrosion/irritant and have the signal word Warning and the hazard statement H314: Causes severe skin burns and eye damage associated with it, in accordance with Regulation EC No. 1272/2008. According to Directive 67/548/EEC, the test substance should be classified as Corrosive (C) and should have the risk phrase R34 : Causes burns, associated with it.
- Executive summary:
In a study conducted by Katz (1977), the test substance, cyclohexyldimethylamine (DMCHA), was tested for its ability to cause irritation when applied to the skin of 6 rabbits. The skin of the test animals was either intact or abraded and 50ml of test substance was applied to each rabbit. Readings on erythema, oedema and corrosion score were made at 4, 24, 48 and 72 hours post application and observations continued for 30 days post application. Under the conditions of this study, the test substance, DMCHA, should be considered to be irritating, based on the results observed following exposure to rabbits. Based on these results, the test substance should be classified as a Category 1B skin corrosion/irritant and have the signal word Warning and the hazard statement H314: Causes severe skin burns and eye damage
associated with it, in accordance with Regulation EC No. 1272/2008. According to Directive 67/548/EEC, the test substance should be classified as Corrosive (C) and should have the risk phrase R34 : Causes burns, associated with it.
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