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EC number: 234-390-0 | CAS number: 11138-47-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
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- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium Perborate Monohydrate (Grade A)
- IUPAC Name:
- Sodium Perborate Monohydrate (Grade A)
- Details on test material:
- -Name of test material (as cited in study report): Sodium Perborate Monohydrate (Grade A)
-Physical state: White granules
-Lot/batch No.: No data
-Stability under test conditions: Sponsor assumed responsibility for purity and stability determinations
-Storage condition of test material: at room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Source: Charles River Lab., Inc., Portage, MI
-Age at study initiation: young adult
-Weight at study initiation: 201-299 g
-Fasting period before study: overnight prior to dosing
-Housing: by sex in groups of 5
-Diet: ad lib.
-Water: ad lib.
-Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
-Temperature (°C): 21-25
-Humidity (%): 21-53
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
-Concentration in vehicle: 5, 10 and 20 % per mL
-Amount of vehicle: 10 mL/kg bw
-Justification for choice of vehicle: preparation of a uniform suspension
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
Rationale for the selection of the starting dose:
A dose range finding was performed using one male and one female rat per dose (500, 1000, 2000 or 5000 mg/kg bw). Based on this results, an initial level of 1000 mg/kg bw and two additional dose levels of 500 and 2000 mg/kg bw were used. - Doses:
- 500, 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 m / 5 f
- Control animals:
- no
- Details on study design:
- -Duration of observation period following administration: 14 days
-Frequency of observations and weighing: Definite study animals were observed for clinical signs and mortality at 1, 2.5, and 4 hours post-dosing. Thereafter all animals were observed for clinical signs daily and twice daily for mortalities.
-Necropsy of survivors and animals found dead performed: yes (gross) - Statistics:
- Average body weights. The oral LD50 was calculated for each sex and for both sexes combined.
Method according to Thakur & Fezio (1981) Drug Chem Toxicol 4 (3), 297 - 305
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 300 mg/kg bw
- 95% CL:
- >= 850 - <= 1 990
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 890 mg/kg bw
- 95% CL:
- >= 530 - <= 1 510
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 120 mg/kg bw
- 95% CL:
- >= 770 - <= 1 630
- Mortality:
- 500 mg: 0/10
1000 mg: 1/5 m and 3/5 f died within 48 hrs after dosing
2000 mg: 5/5 m and 5/5 f died within 24 hrs after dosing - Clinical signs:
- other: >= 500 mg: diarrhoea >= 1000 mg: hypoactivity, ataxia
- Gross pathology:
- 500 mg: alopecia of entire inguinal region in 1 f (most likely coincidental)
1000 mg: enlarged renal pelvis in 1 f (most likely coincidental)
2000 mg: frequent findings located in the gastrointestinal tract (distended stomach with thickened walls, staining of glandular mucosa, entire GI tract filled with clear fluid) both in m and f
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The acute oral toxicity for Sodium Perborate Monohydrate was calculated to be 890 mg/kg for females, 1300 mg/kg for males and 1120 mg/kg for combined sexes.
According to OECD GHS, toxicity category IV (< 300 ≤ 2000) should be assigned. - Executive summary:
With Sodium Perborate Monohydrate an acute oral toxicity study was performed according to US-EPA Guideline OPP 81 -1. Five Sprague-Dawley rats per sex and group were dosed once via gavage with 500, 1000 and 2000 mg/kg bw. Animals were frequently monitored for clinical signs, body weight and mortality. All animals were examined for signs of macroscopic changes.
The acute oral LD50 was calculated to be 890 mg/kg for females, 1300 mg/kg for males and 1120 mg/kg for combined sexes. According to OECD GHS, toxicity category IV (< 300 ≤ 2000) should be assigned.
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