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EC number: 234-390-0 | CAS number: 11138-47-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented with GLP compliance, but data concerning macroscopic or histopathological examinations not reported
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- The ALC (defined as the lowest atmospheric concentration tested that caused the death of 1 or more rats within 14 days of exposure) was calculated in this study. The 4-hours LC50 was re-calculated at a later stage
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 10486-00-7
- EC Number:
- 600-611-8
- Cas Number:
- 10486-00-7
- IUPAC Name:
- 10486-00-7
- Details on test material:
- -Name of test material (as cited in study report): Perboric acid, sodium salt, tetrahydrate
-Physical state: White powder
-Purity: 98.6 %
-Lot/batch No.: 16,703 (Haskell Lab.)
-Other Code: 5# Fine SPBT D50 of 13.3 microns
-Stability under test conditions: Test material was assumed to be stable throughout the exposure phase of the test
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD BR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Source: Charles River Breeding Lab., Kingston, New York
-Age at study initiation: 8 weeks
-Weight at study initiation: 230 - 290 grams
-Fasting period before study: no data
-Housing: In pairs in stainless steel wire-mesh cages
-Diet: ad lib. (except during exposure)
-Water: ad lib. (except during exposure)
-Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
-Temperature (°C): 23 +/- 2
-Humidity (%): 50 +/- 10
-Air changes (per hr): no data
-Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
-Exposure apparatus: K-TRON Model T-20 Twin Screw Volumetric Feeder
-Exposure chamber volume: 6000 mL
-Method of holding animals in test chamber: Rats were restrained in stainless steel cylinders with conical nose piece
-Source and rate of air: ca. 24 - 36 L/min
-Method of conditioning air: High pressure air jet
-System of generating particulates/aerosols: The air flow swept the suspended dust into the 6000 mL cyclonic elutriator. The cyclone removed the larger particles by impaction and allowed the smaller particles to enter a 38 L glass exposure chamber.
-Method of particle size determination: By Sierra Series 210 cascade impactor (MMAD and percent particles with aerodynamic diameters less than 10 um)
-Temperature, humidity, pressure in air chamber: Chamber temperature was measured with a mercury thermometer, relative humidity with a Bendix Model 566 psychrometer, and chamber oxygen content with a Biosystem Model 3100R oxygen analyser
TEST ATMOSPHERE
-Brief description of analytical method used: In 30 min intervals by gravimetric analyses. Known volumes of chamber atmosphere were drawn through pre-weighed Gelman glass fiber filters. Filters were weighed on a Cahn 28 automatic Electrobalance. Atmospheric concentrations were calculated from the filter weight gain, determined from the pre- and post-sampling filter weights.
-Samples taken from breathing zone: yes
VEHICLE
None, air only
TEST ATMOSPHERE
-Particle size distribution: as tabulated below
-MMAD / GSD: as tabulated below - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Mean: 160, 480, 1100 and 2900 mg/m3
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- -Duration of observation period following administration: 14 days
-Frequency of observations and weighing: daily clinical observation and weighing of all survivors
-Necropsy of survivors performed: no data - Statistics:
- LC 50 was calculated separately by Probit Analysis
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 1 165 mg/m³ air
- Based on:
- test mat.
- 95% CL:
- >= 590 - <= 2 909
- Exp. duration:
- 4 h
- Mortality:
- 160 mg/m3: 0/6
480 mg/m3: 1/6
1100 mg/m3: 3/6
2900 mg/m3: 5/6
All deaths occurred within 24 hours. - Clinical signs:
- other: During or immediately following exposure, rats from all groups exhibited gasping, red nasal discharge, and compound-covered faeces. Rats from the >= 480 mg/m3 groups also exhibited laboured breathing. In addition, rats from the >= 1100 mg/m3 groups did no
- Body weight:
- Rats typically had slight to severe (up to 18 % of initial body weight) weight losses within 24 hours of exposure.
- Gross pathology:
- No data
Any other information on results incl. tables
Sodium Perborate Tetrahydrate Atmospheres / Mortality
Concentration (mg/m3) |
% Particles < 10 um ADa |
MMAD (um)b |
Mortality (# deaths/# exposed |
||
Mean |
SD |
Range |
|||
160 |
23 |
140-210 |
94 |
3.3 |
0/6 |
480 |
130 |
280-640 |
94 |
3.5 |
1/6 |
1100 |
240 |
720-1500 |
93 |
3.5 |
3/6 |
2900 |
1500 |
870-4900 |
86 |
4.2 |
5/6 |
a: Percent by weight of particles with aerodynamic diameter (AD) less than 10 um
b: Mass median aerodynamic diameter
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The calculated LC50 in male rats over 4 hours was at 1165 mg/m3 of air.
- Executive summary:
In this study, the 4 h inhalation ALC was calculated in male rats. Mean concentrations of Sodium Perborate Tetrahydrate were 160, 480, 1100 and 2900 mg/m3 and 6 males per dose were used. Mortality was dose-related and the ALC was determined with 480 mg/m3. The substance was classified as moderately toxic.
The LC50 (4 h) was calculated subsequent to the study report finalisation and was at 1165 mg/m3 (equivalent to toxicity category IV of GHS OECD or harmful according to Annex VI of Directive 67/548/EEC).
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