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EC number: 234-390-0 | CAS number: 11138-47-9
In a valid guideline study with GLP compliance sodium perborate monohydrate only showed very mild skin irritating effects in NZW rabbits (Cerven, 1987). In a study with human volunteers only of 23 subjects reacted positive to sodium perborate monohydrate. Therefore, the substance was judged as not skin irritating (Unilever, 1997).Sodium perborate monohydrate was severely eye irritating and corrosive in a valid guideline study with GLP compliance in NZW rabbits (Cerven, 1987).In acute inhalation studies sodium perborate was shown to cause signs of irritation of the respiratory tract. In addition slight and reversible irritating effects on the mucosa of the nose have been reported in workers from some production plants.
Results for sodium perborate monohydrate:
Study: Cerven (1987)
species: NZW rabbit
duration: 4 hrs
score: >= 1.5 to < 2.3
Study: Southwood (1986)
Study: Unilever (1997)
duration: up to 4 hrs
score: 1/23 subjects reacted positive
Results for sodium perborate tetrahydrate:
duration: not rinsed
score: corrosive (corneal opacity, noted in 3/3 eyes, persisted to day 21 in 1/3 eyes. Iritis was noted in 3/3 eyes and cleared by day 21. Moderate to severe conjunctival irritation, noted in 3/3 eyes, cleared by day 21 in 2/3 eyes. However, pale areas in the conjunctiva were noted through day 21)
score: very severe irritant (class 7 on a 1-8 scale)
Study: DuPont (1972)
species: Albino rabbit
score: corrosive (severe corneal damage, severe iritis and severe conjunctivitis in all animals)
score: severe irritant (class 6 on a 1-8 scale)
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