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Description of key information

In a valid guideline study with GLP compliance sodium perborate monohydrate only showed very mild skin irritating effects in NZW rabbits (Cerven, 1987). In a study with human volunteers only of 23 subjects reacted positive to sodium perborate monohydrate. Therefore, the substance was judged as not skin irritating (Unilever, 1997).
Sodium perborate monohydrate was severely eye irritating and corrosive in a valid guideline study with GLP compliance in NZW rabbits (Cerven, 1987).
In acute inhalation studies sodium perborate was shown to cause signs of irritation of the respiratory tract. In addition slight and reversible irritating effects on the mucosa of the nose have been reported in workers from some production plants.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation:

Results for sodium perborate monohydrate:

Study: Cerven (1987)

species: NZW rabbit

duration: 4 hrs

score: >= 1.5 to < 2.3

reversibility: yes

Study: Southwood (1986)

species: NZW rabbit

duration: 4 hrs

score: 0

Study: Unilever (1997)

species: human

duration: up to 4 hrs

score: 1/23 subjects reacted positive

Results for sodium perborate tetrahydrate:

Study: Southwood (1986)

species: NZW rabbit

duration: 4 hrs

score: 0

Eye irritation:

Results for sodium perborate monohydrate:

Study: Cerven (1987)

species: NZW rabbit

duration: not rinsed

score: corrosive (corneal opacity, noted in 3/3 eyes, persisted to day 21 in 1/3 eyes. Iritis was noted in 3/3 eyes and cleared by day 21. Moderate to severe conjunctival irritation, noted in 3/3 eyes, cleared by day 21 in 2/3 eyes. However, pale areas in the conjunctiva were noted through day 21)

Study: Southwood (1986)

species: NZW rabbit

duration: not rinsed

score: very severe irritant (class 7 on a 1-8 scale)

Results for sodium perborate tetrahydrate:

Study: DuPont (1972)

species: Albino rabbit

duration: not rinsed

score: corrosive (severe corneal damage, severe iritis and severe conjunctivitis in all animals)

 

Study: Southwood (1986)

species: NZW rabbit

duration: not rinsed

score: severe irritant (class 6 on a 1-8 scale)


Effects on skin irritation/corrosion: slightly irritating

Effects on eye irritation: corrosive

Effects on respiratory irritation: irritating

Justification for classification or non-classification