Registration Dossier
Registration Dossier
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EC number: 234-390-0 | CAS number: 11138-47-9
Endpoint summary
Administrative data
Description of key information
In a valid guideline study with GLP compliance sodium perborate monohydrate only showed very mild skin irritating effects in NZW rabbits (Cerven, 1987). In a study with human volunteers only of 23 subjects reacted positive to sodium perborate monohydrate. Therefore, the substance was judged as not skin irritating (Unilever, 1997).
Sodium perborate monohydrate was severely eye irritating and corrosive in a valid guideline study with GLP compliance in NZW rabbits (Cerven, 1987).
In acute inhalation studies sodium perborate was shown to cause signs of irritation of the respiratory tract. In addition slight and reversible irritating effects on the mucosa of the nose have been reported in workers from some production plants.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
Results for sodium perborate monohydrate:
Study: Cerven (1987)
species: NZW rabbit
duration: 4 hrs
score: >= 1.5 to < 2.3
reversibility: yes
Study: Southwood (1986)
species: NZW rabbit
duration: 4 hrs
score: 0
Study: Unilever (1997)
species: human
duration: up to 4 hrs
score: 1/23 subjects reacted positive
Results for sodium perborate tetrahydrate:
Study: Southwood (1986)
species: NZW rabbit
duration: 4 hrs
score: 0
Eye irritation:
Results for sodium perborate monohydrate:
Study: Cerven (1987)
species: NZW rabbit
duration: not rinsed
score: corrosive (corneal opacity, noted in 3/3 eyes, persisted to day 21 in 1/3 eyes. Iritis was noted in 3/3 eyes and cleared by day 21. Moderate to severe conjunctival irritation, noted in 3/3 eyes, cleared by day 21 in 2/3 eyes. However, pale areas in the conjunctiva were noted through day 21)
Study: Southwood (1986)
species: NZW rabbit
duration: not rinsed
score: very severe irritant (class 7 on a 1-8 scale)
Results for sodium perborate tetrahydrate:
Study: DuPont (1972)
species: Albino rabbit
duration: not rinsed
score: corrosive (severe corneal damage, severe iritis and severe conjunctivitis in all animals)
Study: Southwood (1986)
species: NZW rabbit
duration: not rinsed
score: severe irritant (class 6 on a 1-8 scale)
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: corrosive
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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