Registration Dossier
Registration Dossier
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EC number: 500-018-3 | CAS number: 9005-64-5 1 - 6.5 moles ethoxylated
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC ≥ 100 mg/L (OECD 301 F, toxicity control, activated sludge)
Key value for chemical safety assessment
Additional information
The toxicity of Sorbitan monolaurate, ethoxylated (CAS No. 9005-64-5) to microorganisms was tested in a toxicity control during a ready biodegradation study (OECD 301 F). If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2008). A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on CO2 evolution (CO2/ThCO2) occurred within 14 days (OECD guideline 301).
For Sorbitan monolaurate, ethoxylated (CAS No. 9005-64-5) a biodegradation test according to OECD guideline 301 F is available (Simon, 2012). The test includes a toxicity control, which contains 100 mg/L of Sorbitan monolaurate, ethoxylated and 100 mg/L of the reference material sodium benzoate. The toxicity control attained 62% degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 100 mg/L can be used as NOEC.
Additionally, a short summary is available for a toxicity test conducted with Sorbitan monolaurate, ethoxylated (CAS No. 9005-64-5), using Pseudomonas putida as test organism. The study was conducted as a limit test at 100 mg/L. No standard guideline was followed. An EC50 of > 100 mg/L is reported. The full report for this study is not available and the documentation is not sufficient to evaluate the reliability of the data. However, the result supports the findings of the key study.
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