Registration Dossier
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EC number: 243-072-0 | CAS number: 19438-60-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Phototransformation in air (4-MHHPAc): Half-life for reaction with photochemically-produced hydroxyl radicals estimated to be 30.1 hours.
Hydrolysis: Half life - at ph 4: 1.43 minutes at 20 deg C; 2.04 minutes at 30 deg C and 0.692 minutes at 50 deg C. at ph 7: 1.90 minutes at 20 deg C; 1.26 minutes at 30 deg C and 0.327 minutes at 50 deg C. at ph 9: 1.27 minutes at 20 deg C; 1.18 minutes at 30 deg C and 0.233 minutes at 50 deg C. As a result of this rapid hydrolysis, in the water compartment, the environmental fate of the acid degradation product (4 -MHHPAc) should be considered.
Biodegradation
Ready biodegradability in water: 2% in 28 days
Bioaccumulation
The potential for bioaccumulation of 4-MHHPAc (the hydrolysis produc of 4-MHHPA) is low, less than 2.4 L/Kg, as expected from low values of log Kow for both substances.
Henry's Law Constant
The Henry's Law constants of 1,2-Cyclohexanedicarboxylic acid, 4-methyl- (4-MHHPAc), as hydrolysis product of hexahydro-4-methylphthalic anhydride, was considered for the environmental assessment. The value of 2.75E-4 Pa m³/mol shows that 4-MHHPAc is essentially non volatile from surface water.
Distribution modelling
Distribution in environmental compartments has been calculated using a Fugacity model according to Mackay, Level III. Distribution in various environmental compartments is estimated as:Air= 0.236%; Water= 4.89%; Soil= 94.8% and Sediment= 0.028%.
.However, the substance is known to be unstable, rapidly hydrolysing to the corresponding di-carboxylic acid in aqueous media and this process is expected to occur in the environment should release occur. As a result the calculated distribution may not be a reasonable estimate. Similar modelling of the degradation product of the substance, 4 -methyl-1,2 -cyclohexanedicarboxylic acid, estimated distribution in the various environmental compartments as:Air= 0.08%; Water= 20.4%; Soil= 79.4% and Sediment= 0.109%.
Refinement of the modelling, undertaken as part of the CSA, and taking account of the uses of the substance, does not support these estimates.
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