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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

No data gaps were identified. The available data are adequate for risk assessment and classification and labelling purposes.

Migrated from Short description of key information:
A study was performed to assess the Contact Hypersensitivity to Diammonium phosphate in the Mouse (Local Lymph Node Assay). The GLP-study was carried out based on the guideline OECD, Section 4, Health Effects, No.429 (2010). Diammonium phosphate was found to be a non-sensitiser.

Justification for selection of skin sensitisation endpoint:
In a LLNA study according to OECD 429 diammonium phosphate was found to be not sensitising. The study is GLP-compliant and has Klimisch score 1.
Read-across justification:
Read across from diammonium phosphate to magnesium ammonium phosphate is considered justified based on following background:
The only difference between the two inorganic salts is the replacement of one ammonia ion by magnesium. Magnesium is, to the current knowledge, not known as a human skin sensitiser. As an ion with a twofold positive charge magnesium is not expected to cross the skin barrier. In addition the different solubilities of the two compounds have to be taken into account. Ammonium dihydrogenorthophosphate is highly soluble in water (400 g/l) whereas magnesium ammonium phosphate is only poorly soluble (100 mg/l). Any reaction with skin humidity would be of minor importance in comparison to ammonium dihydrogenorthophosphate. Any additional testing of magnesium ammonium phosphate would be therefore scientifically unjustified

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2007) and Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures Magnesium ammonium phosphate is not classified as skin sensitiser.