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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

Read across from NaBr to CaBr2 is possible due to the full dissociation of both compounds in water. Na+ and Ca2+ are not toxic in the concentration ranges where Br- is toxic. Therefore only the Br- is responsible for the toxicity effects.

From a read across approach with sodium bromide, the weight of evidence collected in both man and laboratory animals does suggest that sufficient data is already available without the need for additional testing. The target organs, i.e. endocrine and neural systems, have been identified and significant data for the kinetics of bromide are available.

 

The pharmacokinetics of oral and intravenous bromide was studied in 7 healthy young adult volunteers. Oral bioavailability ranged between 75-118%. Elimination T½ was 11.9 ± 1.4 days after oral administration and 9.4 ± 1.5 days after iv administration. The results of the bromide distribution volume suggest that bromide was distributed into the extracellular water space. Bromide was eliminated by the kidney. The clearance rate (Cl) in this study was 26 ± 1.7 mL/kg/day. This value reflects both the glomerular filtration and tubular reabsorption.

 

A study with female Wistar rats fed with sodium bromide showed that chloride depletion prolongs the elimination half-life of bromide. In the rat, bromide half-life is prolonged from approximately 3 days to 25 days on a salt-free diet with tap water.