Registration Dossier
Registration Dossier
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EC number: 209-143-5 | CAS number: 556-88-7
Endpoint summary
Administrative data
Description of key information
Nitroguanidine is not readily/inherently biodegradable under aerobic conditions in standard tests but can be bio transformed co-metabolically by microorganisms after acclimation.
Additional information
The inherent biodegradability of nitroguanidine was determined using OECD method 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test). Based on the data of the individual DOC determinations, no biodegradation of nitroguanidine was observed after 28 days. Results from the literature support the outcome of this OECD Guideline test. Literature results confirm that nitroguanidine is not biodegradable under aerobic conditions but indicate at the same time that nitroguanidine can be co-metabolically degraded by activated sludge microorganisms under anaerobic (Kaplan et al., 1982) and aerobic (Haag et al., 1990 & Spanggord et al., 1987) conditions after acclimation.
Therefore, it can be concluded that nitroguanidine is not readily/inherently biodegradable under aerobic conditions in standard tests but can be bio transformed co-metabolically by microorganisms after acclimation.
As nitroguanidine will not adsorb to soil or sediment organic matter fractions, no sediment/soil simulation testing is necessary. As such, there is no potential for exposure of sediment, even in the event of a direct release of nitroguanidine to aqueous systems (the nitroguanidine will remain in the aqueous phase). Moreover, nitroguanidine is not used in ways that would potentially result in either direct or indirect emissions to soil and nitroguanidine will not adsorb to soil or sediment organic matter fractions. As such, there is no potential for exposure of soil, even in the event of a release of nitroguanidine to air or water (the nitroguanidine will enter or remain in the aqueous phase).
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