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EC number: 500-075-4 | CAS number: 31694-55-0 1 - 6.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
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- Flash point
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 Mar 2011 - 13 Apr 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Bioassay, Labor für biologische Analytik GmbH, INF 515, 69120 Heidelberg
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Glycerol, ethoxylated
- EC Number:
- 500-075-4
- EC Name:
- Glycerol, ethoxylated
- Cas Number:
- 31694-55-0
- Molecular formula:
- (C2 H4 O)n (C2 H4 O)n (C2 H4 O)n C3 H8 O3 3n =>1-<6.5 mol EO
- IUPAC Name:
- Alkoxylation reaction product of glycerin as starter and ethylene oxyde (EO) as monomer
- Details on test material:
- - Name of test material (as cited in study report): Lupranol VP 9209
- Test item number: 11/0080-1
- Physical state: liquid, colorless, clear
- Analytical purity: 100%
- Lot/batch No.: #113
- Expiration date of the lot/batch: 2011-06-13
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Sandhofer Weg 7, 97633 Sulzfeld, Germany
- Animal quality: Crl:WI (Han)
- Age at study initiation: approx. 10 weeks
- Weight at study initiation: animals of comparable weight (± 20% of the mean weight; 175-187 g)
- Fasting period before study (only feed): 16 hours before administration
- Housing: single housing in Makrolon cages (type III)
- Diet: VRF1(P); SDS Special Diets Services, 67122 Altrip, Germany
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12 h / 12 h (6.00 a.m. – 6.00 p.m. / 6.00 p.m. – 6.00 a.m.)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.73 mL/kg bw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- First step: 3 females
Second step: 3 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individual body weights were recorded shortly before administration (day 0), weekly thereafter and on the last day of observation. Recording of clinical signs was performed several times on the day of administration, and at least once daily thereafter each workday.
- Necropsy of survivors performed: yes
- Other examinations performed: A check for any dead or moribund animals was made at least once each workday.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality occurred.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: No clinical signs were observed during the observation period.
- Gross pathology:
- There were no macroscopic pathological findings in the animals sacrificed at the end of the observation period.
- Other findings:
- No other findings were observed.
Any other information on results incl. tables
Table 1: Individual body weight changes of female Wistar rats.
Individual body weight changes |
||||||||||
Administration 1 |
Administration 2 |
|||||||||
Dose |
2000 |
2000 |
||||||||
Sex |
female |
female |
||||||||
Animal number |
R549 |
R550 |
R551 |
Mean weight |
Standard deviation |
R555 |
R556 |
R557 |
Mean weight |
Standard deviation |
Body weight at study day (g): |
|
|
|
|
|
|
|
|
|
|
0 |
187 |
177 |
175 |
179.7 |
6.43 |
180 |
175 |
179 |
178.0 |
2.65 |
7 |
200 |
190 |
186 |
192.0 |
7.21 |
184 |
193 |
200 |
192.3 |
8.02 |
14 |
208 |
200 |
202 |
203.3 |
4.16 |
190 |
207 |
205 |
200.7 |
9.29 |
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