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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available

Data source

Reference
Reference Type:
publication
Title:
A comparison of the elimination and biotransformation of dodecyldimethylamine oxide (DDAO) by rats, rabbits, and man
Author:
Turan T.S. and Gibson W.B.
Year:
1981
Bibliographic source:
Xenobiotica 11, 447-458

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
Metabolism study in rats after oral application of test substance.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Dodecyldimethylamine
EC Number:
203-943-8
EC Name:
Dodecyldimethylamine
Cas Number:
112-18-5
Molecular formula:
C14H31N
IUPAC Name:
N,N-dimethyldodecan-1-amine
Radiolabelling:
yes
Remarks:
C14

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 180 - 230 g (range for animals treated with either DDA (this study) or DDAO)
- Fasting period before study: overnight
- Housing: stainless stell cages
- Individual metabolism cages: yes

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Duration and frequency of treatment / exposure:
single exposure
Doses / concentrations
Remarks:
Doses / Concentrations:
135 mg/kg
No. of animals per sex per dose / concentration:
one animal
Control animals:
no
Positive control reference chemical:
No
Details on dosing and sampling:
Metabolite studies:
- Urine was sampled from 0-24 h. Samples were used for identificatin of metabolites

Results and discussion

Preliminary studies:
no preliminary study
Main ADME results
Type:
metabolism
Results:
metabolite profile was the same as that of the 0-24 h urine from rats dosed with 14C-DDAO (100 mg/kg)

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
The metabolite profile was the same as that of the 0-24 h urine from rats dosed with 14C-DDAO (100 mg/kg). One metabolie that was identifies is N,N-dimethyl-4-aminobutyric acid. No further information available.

Applicant's summary and conclusion

Conclusions:
No bioaccumulation potential based on study results.

Under the conditions of the test the metabolite profile was the same as that of the 0-24 h urine from rats dosed with 14C-DDAO (100 mg/kg).
Executive summary:

One rat was exposed to 135 mg/kg 14C-DDA orally by gavage. The metabolite profile was the same as that of the 0-24 h urine from rats dosed with 14C-DDAO (100 mg/kg).