Registration Dossier
Registration Dossier
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EC number: 229-764-5 | CAS number: 6712-98-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
In a GLP study, conducted according to OECD guideline 201, the phytotoxicity of DEIPA to freshwater green alga was assessed in a static growth inhibition test. The 4-day EC50 was greater than 100 mg/L and the 3- and 4-day NOEC values for algal growth were 100 and 50 mg/L respectively (Kirk et al. 1999).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 50 mg/L
Additional information
In a GLP study (reliability 1), conducted according to OECD guideline 201, the phytotoxicity of DEIPA to fresh water green alga, Selenastrum capricornutum, was assessed in a static growth inhibition test over 4 days. The test was performed with an algal assay medium containing DEIPA at target concentrations of 0 (control), 3.13, 6.25, 12.5, 25, 50 and 100 mg/L (per cent of target values ranged from 84.4 to 104%). Three replicates per concentration were used with an average initial cell density of 15103 cells/ml. Algal cell densities were determined by electron particle counting on day 0 and daily thereafter.The effects of the test substance, measured relative to the controls, ranged from 8.4% growth stimulation at 6.5 mg/L to 18.5% growth inhibition at 100 mg/L by day 4. Total cell counts were not statistically significantly different from controls (p<0.05) with the exception of the value at 100 mg/L on day 4. The 3- and 4-day EC10 values for algal growth based on total cell count were determined to be 74.2 and 68.2 mg/L respectively. The 3 - and 4 -day EC50 and EC90 were greater than 100 mg/L and the 3- and 4-day NOEC values for algal growth were 100 and 50 mg/L respectively (Kirk et al. 1999).
In summarising this study, NICNAS (2009) concluded that DEIPA was not acutely harmful to algae.
Using the ECOSAR (v1.0) programme [class aliphatic amines] in EPISuite (v4.10) a 96-hr EC50 of 39.7 and 39.5 mg/L and a chronic value (ChV) of 46 and 39 mg/L (ppm) for fresh- and salt-water green algae has been predicted (US EPA, 2011).
References
NICNAS (2009). Australian National Industrial Chemicals Notification and Assessment Scheme. Full Public Report. DEIPA. File No: STD/1344. December 2009.http://www.nicnas.gov.au/publications/CAR/new/Std/StdFULLR/std1000FR/std1344FR.pdf
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