Extracts (petroleum), light naphtha solvent

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Episuite and the BCFBAF models are well documented and commonly used QSARs for predicting the bioaccumulation potential of chemicals. Constituents within LOA streams fall within the applicability domain of these models and they have been recommended by ECHA in the Information Requirement Guidelines.

Reason / purpose for cross-reference:

assessment report

Reason / purpose for cross-reference:

(Q)SAR model reporting (QMRF)

Qualifier:

no guideline required

Principles of method if other than guideline:

Formerly called BCFWIN, the BCFBAF program estimates fish bioconcentration factor (BCF) and its logarithm using two different methods. The first is the traditional regression based on log KOW plus any applicable correction factors. The second is the Arnot-Gobas method, which calculates BCF from mechanistic first principles. BCFBAF also incorporates prediction of apparent metabolism half-life in fish, and estimates BCF and BAF for three trophic levels. The program is based on methodologies developed by Arnot-Gobas et al. (2003, 2006, 2008). A 5% lipid normalisation has been used for the Arnot-Gobas method BCF values, as recommended in OECD TG 305.

Key result

Type:

BCF

Value:

> 2 - <= 2 688 L/kg

Basis:

whole body w.w.

Calculation basis:

other: BCF Regression based estimation

Remarks on result:

other: Result from QSAR prediction. Range based on the measured constituents in the streams.

Key result

Type:

BCF

Value:

> 1 - <= 1 415 L/kg

Basis:

whole body w.w.

Calculation basis:

other: BCF Arno-Gobas method (upper trophic) (5% lipid normalisation)

Remarks on result:

other: Result from QSAR prediction. Range based on the measured constituents in the streams.

Details on results:

Of the 240 constituents, 1 has a BCF value of greater than 2000 L/kg ww. Details of the constituents and how their BCF estimates relate to their bioaccumulation assessment are found in the PBT report attached to Section 13 (see cross-reference).

Conclusions:

The predicted BCF values of measured constituents of these streams range from 1 to 2688 L/kg ww. Of the 240 constituents, 1 has a BCF value of greater than 2000 L/kg ww. Details of the constituents and how their BCF estimates relate to their bioaccumulation assessment are found in the PBT report attached to Section 13 (see cross-reference).

Executive summary:

The bioconcentration factor (BCF) values of measured constituents (at equal or above 0.1% w/w) of this category has been predicted using the EPISUITE v4.11 BCFBAF (2017) model, which uses methodology descrived by Arnot-Gobas et al. (2003, 2006, 2008). The predicted BCF values range from 1 to 2688 L/kg ww. Of the 240 constituents, 1 has a BCF value of greater than 2000 L/kg ww.

Description of key information

A measured BCF is not available for any streams in this category. BCF have been predicted for the measured constituents of this category (at equal or above 0.1% w/w). The predicted BCF values range from 1 to 2688 L/kg ww. Of the 240 constituents, 1 has a BCF value of greater than 2000 L/kg ww.

Key value for chemical safety assessment

BCF (aquatic species):

1 678 L/kg ww

Additional information

The bioconcentration factor (BCF) values of measured constituents (at equal or above 0.1% w/w) of this category has been predicted using the EPISUITE v4.11 BCFBAF (2017) model, which uses methodology descrived by Arnot-Gobas et al. (2003, 2006, 2008). The predicted BCF values range from 1 to 2688 L/kg ww. Of the 240 constituents, 1 has a BCF value of greater than 2000 L/kg ww.