Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from December l2th, 1988 to February 9th, 1989
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study performed according to the Test Guideline A.8 of the EEC Directive 84/449/EEC.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name : AF-366
Appearance : white powder
Purity : 97.5 %

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
>= 4.6 - <= 4.8
Temp.:
20 °C
pH:
>= 6.06 - <= 6.54

Applicant's summary and conclusion

Conclusions:
The partition coefficient (n-octanol/water) of the test substance:
log P = 4.70 ± 0.10 (20°C). No unusual effects were observed in the
determinations.