Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from December l2th, 1988 to February 9th, 1989.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study performed according to the Test Guideline A.6 of the EEC Directive 84/449/EEC.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes
Type of method:
column elution method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name : AF-366
Appearance : white powder
Purity : 97.5 %

Results and discussion

Water solubility
Water solubility:
>= 0.037 - <= 0.119 mg/L
Temp.:
20 °C
pH:
>= 6.43 - <= 6.83

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The test substance is practically insoluble in water. Experimental
difficulties were encountered in loading the test substance on silica
and in the wetting procedure which introduce additional experimental
errors resulting in a high standard deviation of the mean value.
The water solubility is 0.078 ± 0.041 mg/1 (20°C).