Registration Dossier
Registration Dossier
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EC number: 310-080-1 | CAS number: 102242-49-9 The complex residue resulting from the vacuum distillation of C6-24 fatty alcohols which is derived from hydrogenation of C6-24 fatty acids methyl esters. It consists predominantly of satd. fatty alcohols having carbon numbers greater than C18, dimerization products, and long chain esters having carbon numbers greater than C32 and boils at > 250°C (482°F) at 10 torr.
Endpoint summary
Administrative data
Description of key information
Eye: Based on the results of the only available (and reliable) study (in vivo), the test substance is considered as not irritating to the eye.
Skin: As the test substance did not induce any skin irritation effects in both an acute dermal toxicity study (dose of 2000 mg/kg bw) and a LLNA assay (at the max. test concentration), it can be concluded that the test substance is not skin irritating.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The eye irritation potential of the test substance was investigated in a study according to OECD test guideline 405.
The amount of 0.1g was applied to eyes of three Russian rabbits and washed out after 1 hour. After 1 hour, redness (score 1) was observed in all rabbits and chemosis of score 1 in one rabbit. No irritant reaction was present after 24, 48 and 72 hours in all rabbits. Therefore, the test substance is considered to be not irritating to the eye.
As the test substance did not induce any skin irritation effects in both a acute dermal toxicity study (dose of 2000 mg/kg bw) and a LLNA-test (max. test concentration of 50%, application volume 25µl), it can be concluded that the test substance is not skin irritating. Therefore, there is no need to further investigate the skin irritation potential.
Justification for classification or non-classification
Eye irritation:
The test substance did not induce any effects after 24, 48 and 72 hours and does therefore not need to be classified.
Skin irritation:
The test substance did not induce skin irritation effects in an acute dermal limit test and in a LLNA for skin sensitisation.
Therefore, it does not need to be classified.
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