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Data on toxicokinetics for N-benzyl-N-C16-18 (even numbered)-alkyl-N-methyl-C16-18 (even numbered)-alkyl-1-aminium chloride (BDHTMAC) are not available.

However, experimental data on toxicokinetic aspects exist for the structural analogue N-C16-C18 (even numbered) -alkyl-N,N-dimethyl- C16-C18 (even numbered)-alkyl-1-aminium chloride (DHTDMAC)

which allow basic considerations concerning toxicokinetic parameter like absorption.

After dermal administration of the radiolabelled structural analogue to rabbits, most of the radioactivity remained at the site of application (88 ± 2.3%). Only traces of administered radioactivity were detected over a 72 h-period in urine (0.15 %), faeces (0.16 %), exhaled carbon dioxide (0.27 %), other skin (0.2%) and cage wash (0.3%) (Drotman R.B.(1977) Metabolism of cutaneously applied surfactants, Cutan.toxic., 3,95 -109).

In in-vitro-studies on human abdominal skin no absorption of the structural analogue was detected (no further information was given, Drotman, 1977).

These experimental findings on the strucutural analogue are supported by the physicochemical properties of N-benzyl-N-C16-18 (even numbered) -alkyl-N-methyl-C16-18 (even numbered)-alkyl-1-aminium chloride (BDHTMAC)

being poorly soluble in water and existing as a quaternary ammonium salt in an ionic state, uncharged molecules, however, are absorbed. Furthermore, the substance has a molecular weight of about 606 -659 g/mol (data from section1.1 identification), usually only substances with lower molecular weight are absorbed. Therefore, the dermal absorption and the concentration of the substance in the skin can be assumed to be very low.

With regard to potential inhalative exposure, due to the low vapour pressure of the dialkylquaternaries the potential for generating vapour and thus inhaling them is minimal. In the unlikely event that aerosols or particulates are inhaled, the pulmonary physiology and clearance dynamics would largely favour the oral absorption than the inhalation. Based on physico-chemical properties, a low inhalative bioavailability can be anticipated.

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