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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline standard with acceptable restrictions (no GLP)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report Date:
1981

Materials and methods

Principles of method if other than guideline:
The inhalation hazard test (IHT; synonymous to IRT, inhalation hazard test) was performed in principle in accordance to Smyth et al., 1962 (Am. Ind. Hyg. Ass. J. 23, 95-107). The aim of the test was to demonstrate the toxicity of an atmosphere saturated with vapours of the volatile components of the test substance at a temperature chosen for vapour generation (i.e. 20 °C for the present test substance). The animals were exposed to the test substance for 7 hours (771 mmHg).
GLP compliance:
no
Test type:
other: Inhalation Hazard Test
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Analytical purity: 99%

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
Body weight at study initiation
- Trial I: Male (3) 255.7 g, female (3) 221g
- Trail II: Male (3) 255.3 g: female (3) 214.3 g

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
The animals inhaled the vapours of the test substance, generated by bubbling 200 l/h air through the substance column of about 5 cm above a fritted glass disc in a glass cylinder.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
Trial I: 0.18 mg/l
Trial II: 0.1 mg/l
No. of animals per sex per dose:
Trial I: 3
Trial II: 3
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: 24h, 48h and at conclusion
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 0.18 other: mg/l
Exp. duration:
7 h
Remarks on result:
other: no mortalities occured
Mortality:
no mortality observed
Clinical signs:
other: no clinical signs of toxicity were observed
Gross pathology:
no organ anomalies were observed

Applicant's summary and conclusion