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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS 1,2-DICHLOROPROPANE
Author:
OECD SIDS
Year:
2003
Bibliographic source:
UNEP PUBLICATIONS
Report date:
2003

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method not available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichloropropane
EC Number:
201-152-2
EC Name:
1,2-dichloropropane
Cas Number:
78-87-5
Molecular formula:
C3H6Cl2
IUPAC Name:
1,2-dichloropropane
Details on test material:
Name. 1,2-dichloropropane

Test animals

Species:
rabbit
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
24 hour
No. of animals per sex per dose:
4 males

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
10 100 mg/kg bw

Any other information on results incl. tables

An LD50 of 8.75 ml/kg bw was reported. This is equivalent to 10,100 mg/kg bw, based on a density of 1.155 g/ml [Source: MacKay et al (1993) Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals, Vol III, p479]

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of the study, the dermal LD50 for PDC in male rabbits was 8.75 ml/kg bw (10100 mg/kg bw).