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Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 Dec 2009 to 11 Feb 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do no effect the quality of the relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Date of inspection: 15-09-2009 Date of Signature: 26-11-2009
Type of method:
thermal analysis

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexane-1,3-dione
EC Number:
207-980-0
EC Name:
Cyclohexane-1,3-dione
Cas Number:
504-02-9
Molecular formula:
C6H8O2
IUPAC Name:
cyclohexane-1,3-dione
Details on test material:
- Name of test material (as cited in study report): 1,3 cyclohexane dione
- Substance type: Powder
- Physical state: Solid
- Analytical purity: 1,3 Cyclohexane Dione >97% W/W
- Impurities (identity and concentrations): Sodium Chloride 1%W/W Maximum
Water 0.5%W/W Maximum
- Composition of test material, percentage of components: 1,3 Cyclohexane Dione 99.2% W/W
Sodium Chloride 0.25%W/W
Water 0.4%W/W

- Purity test date: 18 November 2009
- Lot/batch No.: 184731091224
- Expiration date of the lot/batch: 18 May 2010
- Radiochemical purity (if radiolabelling): N/A
- Stability under test conditions: Stable
- Storage condition of test material: approximately 4 deg C in the dark

Results and discussion

Melting / freezing point
Melting / freezing pt.:
>= 372.5 - <= 373.5 K
Decomposition:
no
Sublimation:
no

Any other information on results incl. tables

Thermograms and thermographic data for Determinations 1 and 2 are shown in Figure 4.1 and Figure 4.2 and in the following tables respectively.

Figure4.1Thermogram – Determination 1 (see image below)

Table4.2Thermographic Data – Determination 1

Thermal Event

Interpretation

Temperature

ºC

K

Endotherm

Melting temperature

100.26

373


Figure4.2Thermogram – Determination 2 (see image below)

Table4.3 Thermographic Data – Determination 2

Thermal Event

Interpretation

Temperature

ºC

K

Endotherm

Melting temperature

100.20

373

Mean melting temperature: 373 ± 0.5 K:

Applicant's summary and conclusion

Conclusions:
The melting point of the test material has been determined to be 373+/-0.5K
Executive summary:

Melting/Freezing Temperature.373 ± 0.5 K, by differential scanning calorimetry, using ASTM E537-86, Method A1 Melting/Freezing Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008.