Registration Dossier
Registration Dossier
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EC number: 205-999-9 | CAS number: 280-57-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 1,4-Diazabicyclo[2.2.2]octane (Q)SAR results were used for the estimation of the long-term toxicity to aquatic invertebrates. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies are not provided.
Assessment
Long-term toxicity of 1,4-Diazabicyclo[2.2.2]octane to Daphnia magna was evaluated by the QSAR Toolbox v4.5 calculation model. The 21-d EC10 was determined to be 12.3 mg/L (BASF SE, 2022). The calculation was performed with the Trend analysis method and the substance is within the applicability domain of the calculation model. This result is supported by a QSAR calculation with KATE2020, which estimated a 21d NOEC for Daphnia magna of 19 mg/L (BASF SE, 2022). The substance is in the applicability domain of the model.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
