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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

With high probability acutely not harmful to fish.

Key value for chemical safety assessment

Additional information

The acute toxicity of ethylamine to fish is assessed using the experimental and estimated data. One acute toxicity study and two static screening tests to fish are available for ethylamine (CAS 75-04-7). The duration of each test was 48 hours and Leuciscus idus was used as a test organisms in each experiment. The resulted LC50 endpoint values are listed in the table below.

Test Type.

LC50 [mg/L]



German Industrial Standard

DIN 38412, L 15 (draft)


100% Ethylamine

Juhnke & Luedermann, 1978



70% aqueous solution

Juhnke & Luedermann, 1978

Screening test, static

> 700

100% Ethylamine

BASF AG, 1977


> 1000

70% aqueous solution

BASF AG, 1977


> 500

100% Ethylamine

BASF AG, rep. no.: PF62, 1977


> 1000

50% aqueous solution

BASF AG, rep. no.: PF62, 1977


The test solutions were not analytically verified. Ethylamine is characterized by a high vapor pressure (140000 Pa, measured, Daubert et. al.) and a high Henry’s Law Constant (1.25 Pa*m3/mol, calc. EPI Suite v 4.11, 2019). The substance has also a high water solubility (1E+06 mg/L, Gestis, 2009). However, the dissociation constant (pKa=10.41, SPARC On-Line Calculator, 2019) indicates that the substance will be present in its ionized form under environmentally relevant conditions (pH 4–9). Hence, the distribution of ethylamine into air may be overestimated. Moreover, the concentrations of ethylamine in the test solutions of a short- and a long-term toxicity study with Ceriodaphnia (IUCLID Ch. 6.1.3 and 6.1.7) were analytically monitored. Analysis of the exposure resulted in measured concentrations which were in agreement with the nominal concentrations over the 24-h exposure period. The deviation of the mean measured concentrations was less than 20% of the nominal values. The highest concentrations (1.7 – 13 mg A.I./L, nominal) showed a higher recovery rate (> 90%) than the lower concentration (0.22 – 0.85 mg A.I/L; 84 – 88% of nominal). According to these measurements, it can be concluded that the concentration of monoethylamine at the highest treatment levels (>1.7 mg A.I./L) is generally stable between the 24-hour renewal periods.

In the screening acute toxicity tests with fish, no mortality was observed at the highest concentrations (48 h, LC50 > 100 mg A.I./L). Since the tested concentrations of ethylamine in these studies were clearly higher than 13 mg A.I./L and the substance is ionized under the environmentally relevant conditions, it can be assumed that the test concentrations were sufficiently stable over the 48-h exposure period to establish the acute toxicity of monoethylamine to aquatic organisms.

Considering all available experimental data for ethylamine, it can be seen, that the LC50 values are higher than 100 mg/L.

In addition, a 96-h LC50 value was estimated with an estimation model QSAR Toolbox v4.3 to be 258 mg/L. The substance was within the applicability domain of the model.

Overall, based on the weight-of-evidence using estimated and measured data, it can be concluded that the LC50 value is higher than 100 mg/L, therefore ethylamine is with high probability not harmful to fish.