Registration Dossier
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EC number: 700-729-0 | CAS number: 1369500-14-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-08-03 to 2011-08-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a relevant guideline without deviations. It was not carried out according to GLP, but it was performed in a test facility which has been certified to be in compliance with the principles of GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- The shake flask method was used rather than the column elution to avoid any changes in crystal structure during deposition
- GLP compliance:
- no
- Remarks:
- GLP compliant facility
- Type of method:
- flask method
- Water solubility:
- 8.7 mg/L
- Temp.:
- 20 °C
- pH:
- >= 7.12 - <= 7.46
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The solubility in water of CA4915 has been determined using the shake flask method to be, correct to two significant figures:
8.7 mg/l at 20 °C - Executive summary:
The shake flask method was used in order not to alter the crystal structure of the test material. A total of six measurements of water solubility were recorded and all were in good agreement with each other giving confidence in the conditions of the study and the result. The study is considered adequate and reliable. The water solubility was determined to be 8.7mg/l at 20°C.
Reference
| Sample number | W1 | W2 | W5 | W2 | W4 | W6 |
| Amount of test sample dispersed in 50ml water (mg) | 10.0 | 10.1 | 10.0 |
10.2 | 10.0 | 10.0 |
| Number of days at 30.0°C | 3 | 2 | 1 | 3 | 2 | 1 |
| Number of days at 25.0°C | 1 | 1 | 1 | 1 | 1 | 1 |
| Centrifugation time (Minutes) | 40 | 40 | 40 | 40 | 40 | 40 |
| Centrifugation Speed (G) | 30000 | 30000 | 30000 | 48000 | 48000 | 48000 |
| pH of clear solution | 7.19 | 7.46 | 7.21 | 7.42 | 7.34 | 7.12 |
Water solubility (mg/l) 1st determination 2nd determination Average |
8.109 8.095 8.102 |
8.828 8.741 8.785 |
9.000 8.968 8.984 |
9.763 9.762 9.763 |
8.379 8.380 8.380 |
8.198 8.175 8.187 |
| Average solubility per centrifuge speed (mg/l) | 8.624 |
8.776 |
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| Relative SD (%) | 4.81 | 8.76 | ||||
| Total average solubility (mg/l) | 8.7 |
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| Total relative SD (%) | 6.8 |
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Description of key information
8.7 mg/L at 20 °C, OECD 105, shake flask method, Vijayakamar 2011
Key value for chemical safety assessment
- Water solubility:
- 8.7 mg/L
- at the temperature of:
- 20 °C
Additional information
Only a single study conducted according to guidelines is available for this endpoint. The study is considered to be relevant, reliable (Klimisch 1) and adequate for the purposes of risk assessment, classification and labelling.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
