Registration Dossier
Registration Dossier
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EC number: 204-614-1 | CAS number: 123-28-4
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Final Safety Assessment of Thiodipropionic Acid and Its Dialkyl Esters as Used in Cosmetics
- Author:
- Diamante C et al.
- Year:
- 2 011
- Bibliographic source:
- International Journal of Toxicology 29(Supplement 3) 137S-150S
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Dilauryl Thiodipropionate
- Author:
- Liebert MA
- Year:
- 1 992
- Bibliographic source:
- Journal of the american college of toxicology
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A makeup foundation containing 0.05% of the test substance was evaluated in a supervised usage test with 30 subjects aged 20 to 58 years.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Kaolin
- Cas Number:
- 1332-58-7
- IUPAC Name:
- Kaolin
- Details on test material:
- - Name of test material (as cited in study report): Dilauryl thiodipropionate
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 30
- Sex: no data
- Age: 20-58 - Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Details on exposure:
- A makeup foundation containing 0.05% DLTDP was evaluated in a supervised usage test with 30 subjects aged 20 to 58 years. The study participants used the product as they would any other product purchased over the counter; the foundation was used daily for 4 weeks. At the end of the fourth week of use, the subjects were checked for any reactions and were asked for their subjective comments. Two subjects did not complete the study; 1 subject discontinued use after 2 weeks, commenting that the product caused acneiform lesions, and the other subject discontinued use after 3 days because of erythema, although erythema was not noted upon objective evaluation.
Results and discussion
- Clinical signs:
- None of the remaining subjects had reactions to the makeup foundation containing 0.05% of the test substance.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
