Registration Dossier
Registration Dossier
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EC number: 209-980-6 | CAS number: 600-00-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Ethyl 2-bromo-2-methylpropionate
- EC Number:
- 209-980-6
- EC Name:
- Ethyl 2-bromo-2-methylpropionate
- Cas Number:
- 600-00-0
- Molecular formula:
- C6H11BrO2
- IUPAC Name:
- ethyl 2-bromo-2-methylpropionate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Enucleated eye
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Duration of treatment / exposure:
- Single administration of 0.1 mL
- Observation period (in vivo):
- 4 hours
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Corneal swelling (%)
- Basis:
- mean
- Time point:
- other: 60 / 120/ 240 minutes
- Score:
- >= 17.8 - <= 36.4
- Max. score:
- 100
- Remarks on result:
- other: A positive response was retained on 120 and 240 minutes
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Ethyl 2-bromoisobutyrate was considered to have the potential to cause severe ocular irritancy. The test material was classified as eye irritant category 1 according to CLP regulation, and the highest hazard statement - H318 : Causes serious eye damage - is then required.
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