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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
11/10/2021
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
Estimated data generated using the EPI suite program developed by the USEPA

Data source

Reference
Title:
Unnamed
Year:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: R6 guidance on QSARS and READ across
Principles of method if other than guideline:
Prediction done using BCFBAF (v3.01) model
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Butylamine
EC Number:
203-699-2
EC Name:
Butylamine
Cas Number:
109-73-9
Molecular formula:
C4H11N
IUPAC Name:
butan-1-amine
Radiolabelling:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
other: Fish

Study design

Route of exposure:
aqueous
Water / sediment media type:
natural water: freshwater

Test conditions

Test temperature:
25°C

Results and discussion

Bioaccumulation factor
Type:
BCF
Value:
ca. 44.22 L/kg
Depuration
Key result
Rate constants
Key result
Value:
3.162
Remarks on result:
other: Non-bioaccumulative

Any other information on results incl. tables

SMILES : NCCCC


CHEM : Butylamine


MOL FOR: C4 H11 N1


MOL WT : 73.14


 


BCFBAF v3.01


Summary Results:


Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)


Biotransformation Half-Life (days) : 0.215 (normalized to 10 g fish)


Log BAF (Arnot-Gobas upper trophic): 0.25 (BAF = 1.78 L/kg wet-wt)


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BCF (Bioconcentration Factor):


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Log Kow (estimated) : 0.83


Log Kow (experimental): 0.97


Log Kow used by BCF estimates:0.97


 


Correction(s): Value


No Applicable Correction Factors


 


Estimated Log BCF = 0.500 (BCF = 3.162 L/kg wet-wt)

Applicant's summary and conclusion

Conclusions:
The bio concentration factor (BCF) of butylamine was estimated to be 3.162 L/kg at 25°C. Which does not exceed the concentration threshold of 2000 indicating that the chemical is not expected to bio accumulate in the food chain.
Executive summary:

BCFBAF model (V3.01) of Estimation Programs interface (EPI Suite, 2017) was used to predictt the bioconcentration factor (BCF) of test chemical  Butylamine cas109-73-9. The  bio concentration factor (BCF) of Butylamine  was estimated to be 3.162 L/kg wet -wt (at 25 °C).Which does not exceed the concentration threshold of 2000 indicating that the chemical is not expected to bio accumulate in the food chain.