4,4'-Isopropylidenediphenol, ethoxylated

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)

Deviations:

no

GLP compliance:

yes

Radiolabelling:

not specified

Vehicle:

no

Test organisms (species):

other: carp

Details on test organisms:

TEST ORGANISM

Common name: Carp
Length at study initiation (length definition, mean, range and SD): 3 - 5 cm
Weight at study initiation (mean and range, SD): 3 g
Method of breeding: SOP/HBS/027

Route of exposure:

aqueous

Test type:

flow-through

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

28 d

Test temperature:

24.1 - 25.0°C

pH:

7.3 - 7.7

Dissolved oxygen:

7.0 - 8.2 mg/L

Nominal and measured concentrations:

4 µg/L, 40 µg/L

Reference substance (positive control):

no

Type:

BCF

Value:

< 41.7 dimensionless

Basis:

whole body w.w.

Time of plateau:

28 d

Calculation basis:

steady state

Remarks on result:

other: Conc.in environment / dose:3.84 µg/L

Type:

BCF

Value:

< 4.2 dimensionless

Basis:

whole body w.w.

Time of plateau:

28 d

Calculation basis:

steady state

Remarks on result:

other: Conc.in environment / dose:38.5 µg/L

Validity criteria fulfilled:

not specified

Conclusions:

The BCF of the test material was < 41.7 at a concentration of 3.84 µg/l, and < 4.2 at a concentration of 38.5 µg/L.

Executive summary:

The aquatic bioaccumulation of the test substance was determined in accordance with the OECD Guideline for Testing of Chemicals 305. The aquatic bioaccumulation was measured in a flow-through fish test, using carp, to assess the bioconcentration in fish. The fish was exposed to the test substance at concentrations of 3.84 µg/L and 38.5 µg/L in flow-through test conditions at 24.1°C-25.0°C for 28 days. The BCF was found to be < 41.7 at 3.84 µg/L and < 4.2 at 38.5 µg/L.

Description of key information

The BCF of the test substance was found to be < 41.7 at a concentration of 3.84 µg/L, and < 4.2 at a concentration of 38.5 µg/L.

Key value for chemical safety assessment

BCF (aquatic species):

4.2 dimensionless

Additional information

A study was conducted to assess the aquatic bioaccumulation of the test substance. The study is considered reliable as it was conducted on the registered substance according to OECD Testing Guideline 305. The BCF of the test substance was found to be < 41.7 at a concentration of 3.84 µg/L, and < 4.2 at a concentration of 38.5 µg/L.