4,4'-Isopropylidenediphenol, ethoxylated

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1970

Report date:

1970

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

(Inhalation hazard test described in the Annex V; adopted 1981)

Deviations:

yes

Remarks:

observation period of 7 days

Principles of method if other than guideline:

Standardized test method (BASF-Test): The test was performed in principle as described in OECD test guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapours of the volatile components of a test substance at 20°C. Young adult laboratory rats, 3 per sex, were exposed sequentially to the vapours generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h. The exposure was subsequently repeated in the same manner. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 7 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period.

GLP compliance:

no

Test type:

other: inhalation risk test

Limit test:

no

Test material

Test material information

1

Reference substance name:

4,4'-Isopropylidenediphenol, ethoxylated

EC Number:

500-082-2

EC Name:

4,4'-Isopropylidenediphenol, ethoxylated

Cas Number:

32492-61-8

Molecular formula:

C15H16O2.(C2H5O)n.(C2H5O)m sum of n+m: >1 - <4.5 moles EO

IUPAC Name:

2-[4-[2-[4-(2-hydroxyethoxy)phenyl]propan-2-yl]phenoxy]ethanol

Test material form:

other: Solid

Details on test material:

Chemical name : 4,4'-isopropylidenediphenol, ethoxylated
EC number : 500-082-2

Based on the qualitative and quantitative information on the composition, the sample used are representative of the boundary composition shared and agree by each registrant.

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION

Rats were exposed for 8 h to a vapour saturated atmosphere. Vapour was generated by bubbling 200 l/h air through the liquid substance column (volume ca. 50 mL) of about 5 cm above a fritted glass disc in a glass cylinder. The air pressure was 754 mm Hg. Temperature in the exposure chamber was 20°C. Concentration was stated in the raw data to be 0.021 mg/L in the case of the 8 h exposure.

TEST ATMOSPHERE

Brief description of analytical method used: no analytics performed
Samples taken from breathing zone: no

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

No verification of the concentration was performed. Nominal concentration: 0.021 mg/L

No. of animals per sex per dose:

2

Control animals:

no

Details on study design:

Duration of observation period following administration: 7 days
Frequency of observations and weighing: group wise documentation on working days
Necropsy of survivors performed: yes
Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: IHT

Effect level:

0.021 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: No mortality.

Mortality:

No mortality observed.

Clinical signs:

other:

Gross pathology:

No abnormality detected.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

The IHT was given as 0.021 mg/L (air). No deaths or abnormalities were recorded. The substance vapours were not toxic at the maximum achievable test concentrations.

Executive summary:

The acute inhalation toxicity of the test substance to rats (strain not specified) was determined in an assay equivalent to the OECD Guideline for Testing of Chemicals 403. The rat was exposed to a whole body dose, nominally stated as 0.021 mg/L. The IHT was given as 0.021 mg/L (air). The animals were observed for 7 days. No deaths or abnormalities were recorded. The substance vapours were not toxic at the maximum achievable test concentrations.