Magnesium di(acetate)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The analogue Calcium Acetate which shares the same functional group with Magnesium Acetate, also has comparable values for the relevant molecular properties for the acute oral toxicity endpoint.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: read-across

Title:

Unnamed

Year:

2010

Materials and methods

Principles of method if other than guideline:

Read-across approach from Letter of Access experimental data (an OECD 401 study) on the analogue Calcium Acetate.

GLP compliance:

not specified

Test type:

other: read-across from OECD 401 study with an analogue

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Calcium di(acetate)

EC Number:

200-540-9

EC Name:

Calcium di(acetate)

Cas Number:

62-54-4

IUPAC Name:

calcium diacetate

Constituent 2

Reference substance name:

calcium acetate

IUPAC Name:

calcium acetate

Details on test material:

- Name of test material (as cited in study report): Calciumacetate
- Molecular formula (if other than submission substance): C2H4O2.1/2Ca
- Molecular weight (if other than submission substance): 158.166
- Smiles notation (if other than submission substance): [Ca+2].[O-]C(C)=O.[O-]C(C)=O
- InChl (if other than submission substance): InChI=1/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

LD50

Effect level:

ca. 1 749.28 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 2 844.94 - 4 177.38 mg/kg bw

Based on:

test mat.

Effect levels 3

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 2 422 mg/kg bw

Based on:

test mat.

Other findings:

Based on the experimental results obtained with the analogue Calcium Acetate (LD 50 2700 mg /kg/bw for female rats = ca. 1943 mg/kg bw, and LD 50 for male rats between 3160 and 4640 mg/kg bw) and the molecular weights, the read-across approach is applied and the LD50 for substance Magnesium Acetate is calculated to be 2422 mg/kw/bw (ca. 1749.28 mg/kg bw for female rats, and between 2844.94 and 4177.38 mg/kg bw for male rats).

The analogue Calcium Acetate, which shares the same functional group with Magnesium Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is - 1.38 for Calcium Acetate and -1.38 for Magnesium Acetate,
- a similar water solubility which is 1.0 g/mL at 25 ºC for Calcium Acetate and 16600 mg/L for Magnesium Acetate at 25 ºC, and
- molecular weights which are 158.166 for Calcium Acetate and 142.40 for Magnesium Acetate.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 for substance Magnesium Acetate is calculated to be 2422 mg/kg/bw (ca. 1749.28 mg/kg bw for female rats, and between 2844.94 and 4177.38 mg/kg bw for male rats).

Executive summary:

Based on the experimental results (reported under the endpoint record 07.02.01_01 CaAc) obtained with the analogue Calcium Acetate (LD 50=2700 mg/kw/bw for female rats = ca. 1943 mg/kg bw, and LD 50 for male rats between 3160 and 4640 mg/kg bw) and the molecular weights, the read-across approach is applied and the LD50 for substance Magnesium Acetate is calculated to be ca. 2422 mg/kg/bw (1749.28 mg/kg bw for female rats, and between 2844.94 and 4177.38 mg/kg bw for male rats).