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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
repeated dose toxicity: oral
Remarks:
other: read-across from a chronic study with an analogue
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The analogue Sodium Acetate which shares the same functional group with Magnesium Acetate, also has comparable values for the relevant molecular properties for the repeated dose toxicity endpoint.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
Read-across approach from published experimental data from a non-standard study on the analogue Sodium acetate.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
Sodium acetate
EC Number:
204-823-8
EC Name:
Sodium acetate
Cas Number:
127-09-3
IUPAC Name:
sodium acetate
Details on test material:
- Name of test material (as cited in study report): sodium acetate
- Molecular formula (if other than submission substance): NaC2H3O2
- Molecular weight (if other than submission substance): 82.03
- Smiles notation (if other than submission substance): [Na+].[O-]C(C)=O
- InChl (if other than submission substance): InChI=1/C2H4O2.Na/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
no effects observed
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
no effects observed
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
Based on the experimental results obtained with the analogue Sodium acetate (NOAEL >= 0.05 mg/kg bw/day in male Long-Evans rats treated daily by drinking water for 8 months), and the molecular weights, the read-across approach was applied and the NOAEL with the substance Magnesium acetate is calculated to be equal or greater than 0.043 mg/kg bw/day.

The analogue Sodium acetate which shares the same functional group with Magnesium acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value, which is -3.72 for Sodium Acetate and -1.38 for Magnesium acetate,
- a high water solubility, which is 1.25 g/mL at 25 ºC for Sodium acetate and 16600 mg/L at 25 ºC for Magnesium acetate, and
- similar molecular weights, which are 82.0 for Sodium acetate and 142.40 for Magnesium acetate.

Effect levels

Dose descriptor:
NOAEL
Effect level:
>= 0.043 other: mg/kg bw/day (estimated)
Based on:
test mat.
Sex:
male
Basis for effect level:
other: overall effects

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

The NOAEL with the substance Magnesium acetate is calculated to be equal or greater than 0.043 mg/kg bw/day.

Applicant's summary and conclusion

Conclusions:
The NOAEL with the substance Magnesium acetate is calculated to be equal or greater than 0.043 mg/kg bw/day.
Executive summary:

Based on the experimental results obtained (reported under the endpoint record 07.05.01_01 NaAc) with the analogue Sodium acetate (NOAEL >= 0.05 mg/kg bw/day in male Long-Evans rats treated daily by drinking water for 8 months), and the molecular weights, the read-across approach was applied and the NOAEL with the substance Magnesium acetate is calculated to be equal or greater than 0.043 mg/kg bw/day.