Magnesium di(acetate)

Genetic toxicity: in vivo

Administrative data

Endpoint:

in vivo mammalian cell study: DNA damage and/or repair

Remarks:

Type of genotoxicity: DNA damage and/or repair

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The analogue Sodium Acetate which shares the same functional group with Magnesium Acetate, also has comparable values for the relevant molecular properties for the genetic toxicity endpoint.

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: read-across

Title:

Unnamed

Year:

2010

Materials and methods

Principles of method if other than guideline:

Read-across approach from published experimental data (Testicular DNA-synthesis inhibition test (DSI test)) on the analogue Sodium acetate.

GLP compliance:

no

Type of assay:

other: read-across from a Testicular DNA-synthesis inhibition test (DSI test) with an analogue

Test material

Test material information

Constituent 1

Reference substance name:

Sodium acetate

EC Number:

204-823-8

EC Name:

Sodium acetate

Cas Number:

127-09-3

IUPAC Name:

sodium acetate

Details on test material:

- Name of test material (as cited in study report): sodium acetate
- Molecular formula (if other than submission substance): NaC2H3O2
- Molecular weight (if other than submission substance): 82.03
- Smiles notation (if other than submission substance): [Na+].[O-]C(C)=O
- InChl (if other than submission substance): InChI=1/C2H4O2.Na/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
- Structural formula attached as image file (if other than submission substance): see Fig.

Results and discussion

Test results

Sex:

male

Genotoxicity:

negative

Toxicity:

no effects

Vehicle controls validity:

valid

Positive controls validity:

not specified

Additional information on results:

Based on published experimental data on the analogue Sodium Acetate which produced no inhibitory effect on DNA-replication in male mice treated with Sodium Acetate, and applying the read-across approach, the substance Magnesium acetate is also considered as not mutagenic under test conditions.

The analogue Sodium acetate which shares the same functional group with Magnesium acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value, which is -3.72 for Sodium Acetate and -1.38 for Magnesium acetate,
- a high water solubility, which is 1.25 g/mL at 25 ºC for Sodium acetate and 16600 mg/L at 25 ºC for Magnesium acetate, and
- similar molecular weights, which are 82.0 for Sodium acetate and 142.40 for Magnesium acetate.

Any other information on results incl. tables

Magnesium acetate is also considered as not mutagenic in male mice.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): negative
Magnesium acetate is also considered as not mutagenic in male mice.

Executive summary:

Based on published experimental data on the analogue Sodium Acetate (reported under the endpoint record 07.06.02_01 NaAc) which produced no inhibitory effect on DNA-replication in male mice treated with Sodium Acetate, and applying the read-across approach, the substance Magnesium acetate is also considered as not mutagenic under test conditions.