Hydrocarbons, C6-C7, isoalkanes, cyclics, <5% n-hexane

Toxicity to terrestrial arthropods

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Administrative data

Endpoint:

toxicity to terrestrial arthropods: long-term

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2019

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Cross-reference

Reason / purpose for cross-reference:

other: QSAR calculation

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

2014

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

2015

Reference 3

Reference Type:

publication

Title:

Unnamed

Year:

1991

Materials and methods

Principles of method if other than guideline:

The target lipid model (2015) and equilibrium partitioning model as described in the cited references were used to determine soil or sediment effect levels following an estimation of initial loading of the registered substance and its constituents in the substrate. A full explanation of the calculation method is provided in the 'attached justification'.

For model description and justification of QSAR prediction: see fields 'justification for type of information' and 'attached justification'

Test material

Test material information

Constituent 1

Test organisms

Test organisms (species):

Folsomia candida

Animal group:

Collembola (soil-dwelling springtail)

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

28 d

Dose descriptor:

LC50

Effect conc.:

81 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Effect concentrations 2

Duration:

28 d

Dose descriptor:

EC10

Effect conc.:

15.5 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Remarks on result:

other: chronic endpoints were estimated using typical acute-to-chronic ratio of 5.22 (McGrath et al., 2018)

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Executive summary:

The registered substance is a complex petroleum UVCB whose constituents have variable physicochemical properties. Therefore, a modeling framework is needed to account for the bioavailability of the constituents in the mixture, which was then used to predict the toxicity of the substance as a whole. The target lipid model (TLM) and HC5, have been applied to soils and sediment using equilibrium partitioning (EqP) model. As such, modeled data are considered fit for purpose.