Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-271-2 | CAS number: 1317-40-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification of the read-across from copper (II) oxide to copper sulphide:
In order to minimise animal testing, available data on copper(II) oxide have been read-across to copper sulphide (copper (II) oxide is unclassified on the basis of acute toxicity, irritation and sensitisation potential). These are both simple inorganic copper(II) compounds with very low water solubility and an anion of no toxicological concern. In fact, theoretical estimates for the solubility of copper sulphide are orders of magnitude lower than those of the oxide, ranging from 3.31E-11 µg/L to 2.4E-10 µg/L. It is generally accepted that lower water solubility can be equated to lower bioavailability and hence acute toxicity; an effect clearly seen by a comparison of copper(II) oxide toxicity with that of the more soluble copper(I) oxide. On this basis, it is considered that a read-across of the acute toxicological, irritation and sensitisation properties from copper(II) oxide to copper sulphide represents a reasonable worst-case approach, and leads to that conclusion that copper sulphide is similarly unclassified. This conclusion is supported by the fact that acute oral and irritation testing carried out with dicopper sulphide confirms that this marginally more soluble compound is also unclassified.
Skin irritation/corrosion:
A GLP-compliant skin irritation/corrosivity study was conducted in the rabbit with the read-across compound copper (II) oxide in accordance with OECD Guidelien 404 (Sanders, 2002c). No erythema or oedema was recorded in any animal at any time. It is therefore concluded that copper sulphide is not classified on the basis of skin irritation/corrosivity.
Eye irritation/corrosion:
A GLP-compliant eye irritation study was conducted in New
Zealand White rabbits with the read-across compound copper (II) oxide in
accordance with OECD Guideline 405 (Sanders, 2002d). Average scores for
corneal opacity, iris, conjunctival redness and chemosis were 0.33,
0.22, 0.77 and 0.55 respectively. All effects were fully reversible. It
is therefore concluded that copper sulphide is not classified on the
basis of eye irritation/corrosivity.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
