Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-314-6 | CAS number: 2409-55-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: insufficient documented, few experimental details
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 949
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- the test substance was applied on gauze held in place by a flexible wire screen according the method of Draize et al.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2-tert-butyl-p-cresol
- EC Number:
- 219-314-6
- EC Name:
- 2-tert-butyl-p-cresol
- Cas Number:
- 2409-55-4
- Molecular formula:
- C11H16O
- IUPAC Name:
- 2-tert-butyl-4-methylphenol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- 2200 mg/kg
- No. of animals per sex per dose:
- 1
- Control animals:
- not required
- Details on study design:
- no further data
- Statistics:
- no data - only one animal used
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 2 200 mg/kg bw
- Mortality:
- 1 animals used. the animal died after 72 hours after exposure. this may be due to secondary effects from the severe chemical burn rather than from systemic absorption of the compound
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- immediate irritation, becoming erythematous. leather-like appearance within 4 hr. complete necrosis and eventual sloughing and scar formation
Any other information on results incl. tables
similar local effects as with carvacrol
Applicant's summary and conclusion
- Executive summary:
method: the test substance was applied on gauze held in place by a flexible wire screen according the method of Draize et al.
result: LD50 = 2200 mg/kg/24 h; substance seems to have low systemic toxicity, but may cause fatalities through exposure of relatively large areas of the skin. this may be due to secondary effects from the severe chemical burn rather than from systemic absorption of the compound themselve (LD50 = 2200 mg/kg bw is also quoted in the MAK statement)
reference: McOmie (1949)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
