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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented, acceptable publication

Data source

Reference
Reference Type:
publication
Title:
Allergic Contact Dermatitis in Dentists and Dental Nurses.
Author:
Kiec-Swierczyniska M, Krecisz B
Year:
2002
Bibliographic source:
Exog. Dermatol. 1: 27-31

Materials and methods

Type of sensitisation studied:
skin
Study type:
survey
Principles of method if other than guideline:
The incidence of allergic contact dermatitis was analysed in 79 dentists and 46 dental nurses referred during 1990 - 2000 for consultation to the Nofer Institute of Occupational Medicine, Lodz, Poland. Allergic contact dermatitis was diagnosed from the positive results of patch tests and type I allergy to latex and common environmental allergens from the positive results of prick tests.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
occupational
Ethical approval:
not specified
Subjects:
- Number of subjects exposed: 125 (79 dentists and 46 dental nurses)
- Sex: 72 women and 7 men (dendists) and 46 women (dental nurses)
Controls:
none
Route of administration:
dermal
Details on study design:
Type of test used: patch test (epicutaneous test)

Administration: Patch tests were applied and inspected according to the guidelines of the International Contact Dermatitis Research Group (Fregert S: Manual of Contact Dermatitis, ed 2., Copenhagen, Munksgaard, 1981).

Results and discussion

Results of examinations:
- Contact dermatitis (at least 1 positive result of the patch test) was diagnosed in 56 (70.9 %) dentists and 34 (73.9 %) dental nurses. Among the most frequent sensitizers were acrylates with 25.3 %. Allergy to acrylates was detected in 20 dentists of which 8 reacted to 2-hydroxyethyl acrylate and 5 to 2-hydroxypropyl acrylate, respectively.
- Number of subjects with positive reactions: 5/20

Applicant's summary and conclusion