Acrylic acid, monoester with propane-1,2-diol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: In the study report, test parameters didn’t totally comply with the specific testing guideline, but were sufficient to accept data and study was conducted prior to the advent of GLP regulations (1982).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Materials and methods

Principles of method if other than guideline:

Inhalation Hazard Test

GLP compliance:

no

Remarks:

(Study was conducted prior to the advent of GLP regulations)

Test type:

other: Inhalation Hazard Test

Test material

Test material information

Constituent 1

Reference substance name:

Acrylic acid, monoester with propane-1,2-diol

EC Number:

247-118-0

EC Name:

Acrylic acid, monoester with propane-1,2-diol

Cas Number:

25584-83-2

Molecular formula:

C6H10O3

IUPAC Name:

Reaction mass of 2-hydroxy-1-methylethyl acrylate and 2-hydroxypropyl acrylate

Details on test material:

- Analytical purity: no data

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

Concentrated vapour was generated in a glass washing bottle by passing dried air at 2.5 liters per min through a fritted glass disc immersed to a depth of at least 1-1/2 inches in the chemical which was delivered to rats in a 9 L glass exposure chamber. Mean vapour concentration was calculated from the loss in weight of the liquid or estimated from the vapour pressure at the actual temperature of the chemical during aeration.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

Concentrations:

0.833 mg/L or 156 ppm

No. of animals per sex per dose:

6

Control animals:

not specified

Statistics:

no data

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

other: IHT

Effect level:

0.833 mg/L air (nominal)

Exp. duration:

8 h

Remarks on result:

other: Substantially vapour generated at approximately 21 °C for 8 hours killed 0/6 rats exposed to the concentration of 0.833 mg/L or 156 ppm of test substance through inhalation route.

Mortality:

No mortality was observed.

Clinical signs:

other: Extremities irritated and hyperactive at 8 hours.

Gross pathology:

Nothing significant was observed.

Any other information on results incl. tables

Substantially vapour generated at approximately 21 °C for 8 hours killed 0 / 6 rats exposed to the concentration of 0.833 mg/ L or 156 ppm of test substance through inhalation route.