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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: In the study report, test parameters didn’t totally comply with the specific testing guideline, but were sufficient to accept data and study was conducted prior to the advent of GLP regulations (1982).

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967

Materials and methods

Principles of method if other than guideline:
Inhalation Hazard Test
GLP compliance:
no
Remarks:
(Study was conducted prior to the advent of GLP regulations)
Test type:
other: Inhalation Hazard Test

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Concentrated vapour was generated in a glass washing bottle by passing dried air at 2.5 liters per min through a fritted glass disc immersed to a depth of at least 1-1/2 inches in the chemical which was delivered to rats in a 9 L glass exposure chamber. Mean vapour concentration was calculated from the loss in weight of the liquid or estimated from the vapour pressure at the actual temperature of the chemical during aeration.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
0.833 mg/L or 156 ppm
No. of animals per sex per dose:
6
Control animals:
not specified
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: IHT
Effect level:
0.833 mg/L air (nominal)
Exp. duration:
8 h
Remarks on result:
other: Substantially vapour generated at approximately 21 °C for 8 hours killed 0/6 rats exposed to the concentration of 0.833 mg/L or 156 ppm of test substance through inhalation route.
Mortality:
No mortality was observed.

Clinical signs:
other: Extremities irritated and hyperactive at 8 hours.
Gross pathology:
Nothing significant was observed.

Any other information on results incl. tables

Substantially vapour generated at approximately 21 °C for 8 hours killed 0 / 6 rats exposed to the concentration of 0.833 mg/ L or 156 ppm of test substance through inhalation route.

Applicant's summary and conclusion