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EC number: 241-460-4 | CAS number: 17439-11-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
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- Stability: thermal, sunlight, metals
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- Dissociation constant
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- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Recent, non-GLP published study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Details on sampling:
- No details.
- Vehicle:
- no
- Details on preparation and application of test substrate:
- Four fluorides were applied into the soil in sublethal concentrations.
- Test organisms (species):
- Eisenia fetida
- Details on test organisms:
- No further details on test organism.
- Study type:
- laboratory study
- Substrate type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 22 wk
- Post exposure observation period:
- No post exposure observation period.
- Test temperature:
- Not stated
- pH:
- Not stated
- Moisture:
- Not stated
- Details on test conditions:
- No further details given.
- Nominal and measured concentrations:
- nominal
- Reference substance (positive control):
- no
- Duration:
- 22 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 200 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Remarks on result:
- other: Sodium fluoride
- Duration:
- 22 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 750 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Remarks on result:
- other: Potassium fluoride
- Details on results:
- In higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced growth of E.fetida significantly. Calcium fluoride had no effect. The maturity was delayed through higher concentrations of NaF and KF in the substrate. Most cocoons were found in the experiment with the sodium salt of fluoro acetic acid. Small concentrations of sodium fluoride and potassium fluoride reduced it. Only sodium fluoride reduced the number of hatchlings per cocoon significantly. At the end of the test, all worms from the variants with sodium fluoride, potassium fluoride and calcium fluoride had a significant higher fluoride concentration.
- Results with reference substance (positive control):
- Not relevant
- Reported statistics and error estimates:
- No reported statistics and error estimates.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- In higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced the growth of E.fetida significantly. Effects on the maturity and fertility of the earthworms was also noted in the presence of sodium fluoride and potassium fluoride.
- Executive summary:
The toxicity of various fluoride compounds to Eisenia fetida was investigated over a period of 22 weeks. At higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced significantly. Calcium fluoride had no effect. The rate of maturity of the earthworms was also significantly reduced when sodium fluoride and potassium fluoride was used. The number of hatchlings was reduced in the presence of sodium fluoride, while the number of cocoons was reduced in the presence of a low concentration of sodium fluoride and potassium fluoride.
No data is available on the effects of hydrogen fluoride on the growth, maturity and and fertility of the earthworm. However, in a terrestial environment the submission substance exists predominantly as fluoride ions. Therefore the results above are a good indication of the behaviour of hydrogen fluoride in the terrestial environment.
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
Dihydrogen hexafluorotitanate is an inorganic substance which will rapidly dissociate into fluoride, hydrogen and titanium ions upon dissolution in the environment. However, hydrogen and titanium ions do not remain as such in solution, only fluoride ions do. The approach follows scenario 1 of the RAAF (ECHA 2017).
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source
sodium fluoride (CAS 7681-49-4)
potassium fluoride (CAS 7789-23-3)
Target
Dihydrogen hexafluorotitanate (CAS 17439-11-1)
3. ANALOGUE APPROACH JUSTIFICATION
Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, the NOEC of 1200 mg F/kg for the long-term (154 days) toxicity (growth, maturity and hatchability of coccons) of sodium fluoride to Eisenia fetida (according to OECD 207) is read-across resulting in a NOEC of 1725.5 mg/kg for dihydrogen hexafluorotitanate.
4. DATA MATRIX
see attached read-across statement in section 13.2 - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 22 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 200 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Remarks on result:
- other: Sodium fluoride
- Duration:
- 22 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 750 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Remarks on result:
- other: Potassium fluoride
- Details on results:
- In higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced growth of E.fetida significantly. Calcium fluoride had no effect. The maturity was delayed through higher concentrations of NaF and KF in the substrate. Most cocoons were found in the experiment with the sodium salt of fluoro acetic acid. Small concentrations of sodium fluoride and potassium fluoride reduced it. Only sodium fluoride reduced the number of hatchlings per cocoon significantly. At the end of the test, all worms from the variants with sodium fluoride, potassium fluoride and calcium fluoride had a significant higher fluoride concentration.
- Results with reference substance (positive control):
- Not relevant
- Reported statistics and error estimates:
- No reported statistics and error estimates.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- In higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced the growth of E.fetida significantly. Effects on the maturity and fertility of the earthworms was also noted in the presence of sodium fluoride and potassium fluoride.
- Executive summary:
The toxicity of various fluoride compounds to Eisenia fetida was investigated over a period of 22 weeks. At higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced significantly. Calcium fluoride had no effect. The rate of maturity of the earthworms was also significantly reduced when sodium fluoride and potassium fluoride was used. The number of hatchlings was reduced in the presence of sodium fluoride, while the number of cocoons was reduced in the presence of a low concentration of sodium fluoride and potassium fluoride.
No data is available on the effects of hydrogen fluoride on the growth, maturity and and fertility of the earthworm. However, in a terrestial environment the submission substance exists predominantly as fluoride ions. Therefore the results above are a good indication of the behaviour of hydrogen fluoride in the terrestial environment.
Referenceopen allclose all
At higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced the growth of E. fetida significantly. Calcium fluoride had no effect. The rate of maturity of the earthworms was also significantly reduced when sodium fluoride and potassium fluoride was used. The number of hatchlings was reduced in the presence of sodium fluoride, while the number of cocoons was reduced in the presence of a low concentration of sodium fluoride and potassium fluoride.
No data is available on the effects of hydrogen fluoride on the growth, maturity and and fertility of the earthworm. However, the submission substance will be unstable in the terrestrial environment and exposure of terrestrial organisms will predominantly be to fluoride ions. Therefore the results above are a good indication of the behaviour of hydrogen fluoride in the terrestrial environment.
At higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced the growth of E. fetida significantly. Calcium fluoride had no effect. The rate of maturity of the earthworms was also significantly reduced when sodium fluoride and potassium fluoride was used. The number of hatchlings was reduced in the presence of sodium fluoride, while the number of cocoons was reduced in the presence of a low concentration of sodium fluoride and potassium fluoride.
No data is available on the effects of hydrogen fluoride on the growth, maturity and and fertility of the earthworm. However, the submission substance will be unstable in the terrestrial environment and exposure of terrestrial organisms will predominantly be to fluoride ions. Therefore the results above are a good indication of the behaviour of hydrogen fluoride in the terrestrial environment.
Description of key information
Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution, it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, the NOEC of 1200 mg F/kg for the long-term (154 days) toxicity (growth, maturity and hatchability of coccons) of sodium fluoride to Eisenia fetida (according to OECD 207) is read-across resulting in a NOEC of 2828.5 mg/kg for dihydrogen hexafluorotitanate (based upon a molecular weight conversion and correction to max. purity).
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 2 828.5 mg/kg soil dw
Additional information
Dihydrogen hexafluorotitanate
Since dihydrogen hexafluorotitanate rapidly dissociates into fluoride, hydrogen and titanium ions upon dissolution in the environment, and only fluoride but not hydrogen and titanium ions will remain as such in solution,it can be assumed that toxicity (if any) will be driven by the fluoride anion. Therefore, full read-across of soil toxicity data of potassium fluoride (CAS #7789-23-3) and other fluorides based upon a molecular weight conversion (and correction to max. purity) is justified (see below).
Fluorides
The toxicity of various fluoride compounds to Eisenia fetida was investiated over a period of 22 weeks. At higher concentrations sodium fluoride, potassium fluoride and the sodium salt of fluoroacetic acid reduced significantly. Calcium fluoride had no effect. The rate of maturity of the earthworms was also significantly reduced when sodium fluoride and potassium fluoride was used. The number of hatchlings was reduced in the presence of sodium fluoride, while the number of cocoons was reduced in the presence of a low concentration of sodium fluoride and potasium fluoride (Vogel & Ottow, 1992).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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