Registration Dossier
Registration Dossier
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EC number: 204-602-6 | CAS number: 123-11-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- The Metabolism of Vetraldehyde and Veratric Acid in the Rabbit
- Author:
- Sammons HC and Williams RT
- Year:
- 1 945
- Bibliographic source:
- Biochemical Journal 40: 223-227
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Determination of test substance metabolites in the urine after oral treatment.
- GLP compliance:
- no
Test material
- Reference substance name:
- Anisaldehyde
- EC Number:
- 204-602-6
- EC Name:
- Anisaldehyde
- Cas Number:
- 123-11-5
- Molecular formula:
- C8 H8 O2
- IUPAC Name:
- 4-methoxybenzaldehyde
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): anisaldehyde; p-methoxybenzaldehyde
No additional details provided.
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No additional details provided.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- No additional details provided
- Duration and frequency of treatment / exposure:
- Not specified
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 mg per animal
- No. of animals per sex per dose / concentration:
- a total of 6 animals (sex not specified)
- Control animals:
- not specified
- Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine
- Time and frequency of sampling: the urine was collected during 24 hours
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Anisoylglucuronide was prepared from the 24-hour urine anisaldehyde-fed rabbits.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
